Synthesis, Spectral Characterization, and In Vitro Cytotoxicity of N-2′-Hydroxyethyl-Substituted Azacholestanes Prepared from 6-Oxocholestanes by Modified Schmidt Reaction
المؤلفون المشاركون
Khan, Suraiya
Alam, Mahboob
Park, Soonheum
Lee, Dong-Ung
Nami, Shahab A. A.
Mushfiq, M.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The present paper reports the synthesis and spectroscopic characterization of few N-2′-hydroxyethyl-substituted azacholestanes using BF3-OEt2, TiCl4, SnCl4, and H2SO4 as catalysts in moderate yields by a modified version of Schmidt reaction.
A notable feature is the passivity of SnCl4 in case of 3β-acetoxy-N-2′-hydroxyethyl-6-aza-B-homo-5α-cholestan-7-one and 3β-chloro-N-2′-hydroxyethyl-6-aza-B-homo-5α-cholestan-7-one.
However, the reaction was unsuccessful in case of N-2′-Hydroxyethyl-6-aza-B-homo-5α-cholestan-7-one.
Another striking aspect is the attainment of high yield in case of H2SO4 as catalyst.
The semisolid compounds are characterized using various spectroscopic techniques such as FT-IR, 1H-NMR and mass spectra, and microanalytical data.
A reaction mechanism has been proposed on the basis of previous studies.
Moreover, the compounds have also been screened for their in vitro cytotoxicity against human colon carcinoma cell line, HCT116, and human liver hepatocellular carcinoma cell line, HepG2, using doxorubicin as standard.
On the basis of IC50 values, 3β-chloro-N-2′-hydroxyethyl-6-aza-B-homo-5α-cholestan-7-one (5) was found to inhibit the cancer cells most effectively.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nami, Shahab A. A.& Khan, Suraiya& Alam, Mahboob& Mushfiq, M.& Lee, Dong-Ung& Park, Soonheum. 2012. Synthesis, Spectral Characterization, and In Vitro Cytotoxicity of N-2′-Hydroxyethyl-Substituted Azacholestanes Prepared from 6-Oxocholestanes by Modified Schmidt Reaction. Journal of Spectroscopy،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-447868
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nami, Shahab A. A.…[et al.]. Synthesis, Spectral Characterization, and In Vitro Cytotoxicity of N-2′-Hydroxyethyl-Substituted Azacholestanes Prepared from 6-Oxocholestanes by Modified Schmidt Reaction. Journal of Spectroscopy No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-447868
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nami, Shahab A. A.& Khan, Suraiya& Alam, Mahboob& Mushfiq, M.& Lee, Dong-Ung& Park, Soonheum. Synthesis, Spectral Characterization, and In Vitro Cytotoxicity of N-2′-Hydroxyethyl-Substituted Azacholestanes Prepared from 6-Oxocholestanes by Modified Schmidt Reaction. Journal of Spectroscopy. 2012. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-447868
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-447868
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر