Time-Dependent Prognostic Impact of Circulating Tumor Cells Detection in Non-Metastatic Breast Cancer : 70-Month Analysis of the REMAGUS02 Study

المؤلفون المشاركون

Reyal, Fabien
Ngo, Charlotte
Lebofsky, Ronald
Alran, Séverine
Giacchetti, Sylvie
Belin, Lisa
Bidard, François-Clément
Marty, Michel
Delaloge, Suzette
Lerebours, Florence
Pierga, Jean-Yves

المصدر

International Journal of Breast Cancer

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-05-09

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Introduction.

In non-metastatic breast cancer patients, the REMAGUS02 neoadjuvant study was the first to report a significant impact of circulating tumor cells (CTCs) detection by the CellSearch system on the distant metastasis-free survival (DMFS) and overall survival (OS) endpoints.

However, these results were only reported after a short follow-up.

Here, we present the updated data, with a longer follow-up.

Material and Methods.

CTC count was performed before and after neoadjuvant chemotherapy in 118 patients and correlated to survival.

Results.

CTC count results were available before and/or after neoadjuvant chemotherapy in 115 patients.

After a median follow-up of 70 months, detection of ≥1 CTC/7.5 mL before chemotherapy (N=95) was significantly associated with DMFS (P=0.04) and OS (P=0.03), whereas postchemotherapy CTC detection (N=85) had no significant impact.

In multivariable analysis, prechemotherapy CTC and triple negative phenotype were the two independent prognostic factors for survival.

We observed that the CTC impact is most significant during the first three years of follow-up.

Discussion.

We confirm that the detection of CTC is independently associated with a significantly worse outcome, but mainly during the first 3-4 years of follow-up.

No prognostic impact is seen in patients who are still relapse-free at this moment.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Bidard, François-Clément& Belin, Lisa& Delaloge, Suzette& Lerebours, Florence& Ngo, Charlotte& Reyal, Fabien…[et al.]. 2013. Time-Dependent Prognostic Impact of Circulating Tumor Cells Detection in Non-Metastatic Breast Cancer : 70-Month Analysis of the REMAGUS02 Study. International Journal of Breast Cancer،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-448077

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Bidard, François-Clément…[et al.]. Time-Dependent Prognostic Impact of Circulating Tumor Cells Detection in Non-Metastatic Breast Cancer : 70-Month Analysis of the REMAGUS02 Study. International Journal of Breast Cancer No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-448077

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Bidard, François-Clément& Belin, Lisa& Delaloge, Suzette& Lerebours, Florence& Ngo, Charlotte& Reyal, Fabien…[et al.]. Time-Dependent Prognostic Impact of Circulating Tumor Cells Detection in Non-Metastatic Breast Cancer : 70-Month Analysis of the REMAGUS02 Study. International Journal of Breast Cancer. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-448077

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-448077