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Coagulopathy and Extremely Elevated PTINR after Dabigatran Etexilate Use in a Patient with End-Stage Renal Disease
المؤلفون المشاركون
Sayeed, Abrar
Abela, George S.
Kim, Joonseok
Laird-Fick, Heather S.
Gourineni, Venu
Yadava, Mrinal
An, In Chul
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-18
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Introduction.
Dabigatran is an oral direct thrombin inhibitor which has been approved for prophylaxis of stroke in patients with atrial fibrillation.
The use of dabigatran etexilate increased rapidly due to many benefits.
However, questions have been raised constantly regarding the safety of dabigatran etexilate.
Case.
A 58-year-old Caucasian male with a history of recurrent paroxysmal atrial fibrillation status after pacemaker and end-stage renal disease on hemodialysis came to the Emergency Department with the complaint of severe epistaxis.
He had been started on dabigatran 150 mg twice a day about 4 months ago as an outpatient by his cardiologist.
His prothrombin time (PT) was 63 seconds with international normalized ratio (INR) of 8.8 and his activated partial thromboplastin time (aPTT) was 105.7 seconds.
Otherwise, all labs were unremarkable including the liver function test.
Dabigatran was stopped immediately.
His INR and aPTT trended downward, reaching normal levels 5 days after admission.
Conclusion.
Dabigatran is contraindicated in patients with severe kidney insufficiency as it is predominantly excreted via the kidney (~80%).
Elderly patients over 75 and patients with chronic renal impairment should be carefully evaluated before starting dabigatran.
Despite studies showing only mild increase in aPTT and PT/INR in patients receiving dabigatran, close monitoring may be reasonable in patients with renal insufficiency.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Joonseok& Yadava, Mrinal& An, In Chul& Sayeed, Abrar& Laird-Fick, Heather S.& Gourineni, Venu…[et al.]. 2013. Coagulopathy and Extremely Elevated PTINR after Dabigatran Etexilate Use in a Patient with End-Stage Renal Disease. Case Reports in Medicine،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-448168
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Joonseok…[et al.]. Coagulopathy and Extremely Elevated PTINR after Dabigatran Etexilate Use in a Patient with End-Stage Renal Disease. Case Reports in Medicine No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-448168
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Joonseok& Yadava, Mrinal& An, In Chul& Sayeed, Abrar& Laird-Fick, Heather S.& Gourineni, Venu…[et al.]. Coagulopathy and Extremely Elevated PTINR after Dabigatran Etexilate Use in a Patient with End-Stage Renal Disease. Case Reports in Medicine. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-448168
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448168
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