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Viral Infection : An Evolving Insight into the Signal Transduction Pathways Responsible for the Innate Immune Response
المؤلفون المشاركون
Kotwal, Girish J.
Hatch, Steven
Marshall, William L.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The innate immune response is initiated by the interaction of stereotypical pathogen components with genetically conserved receptors for extracytosolic pathogen-associated molecular patterns (PAMPs) or intracytosolic nucleic acids.
In multicellular organisms, this interaction typically clusters signal transduction molecules and leads to their activations, thereby initiating signals that activate innate immune effector mechanisms to protect the host.
In some cases programmed cell death—a fundamental form of innate immunity—is initiated in response to genotoxic or biochemical stress that is associated with viral infection.
In this paper we will summarize innate immune mechanisms that are relevant to viral pathogenesis and outline the continuing evolution of viral mechanisms that suppress the innate immunity in mammalian hosts.
These mechanisms of viral innate immune evasion provide significant insight into the pathways of the antiviral innate immune response of many organisms.
Examples of relevant mammalian innate immune defenses host defenses include signaling to interferon and cytokine response pathways as well as signaling to the inflammasome.
Understanding which viral innate immune evasion mechanisms are linked to pathogenesis may translate into therapies and vaccines that are truly effective in eliminating the morbidity and mortality associated with viral infections in individuals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kotwal, Girish J.& Hatch, Steven& Marshall, William L.. 2012. Viral Infection : An Evolving Insight into the Signal Transduction Pathways Responsible for the Innate Immune Response. Advances in Virology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-448172
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kotwal, Girish J.…[et al.]. Viral Infection : An Evolving Insight into the Signal Transduction Pathways Responsible for the Innate Immune Response. Advances in Virology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-448172
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kotwal, Girish J.& Hatch, Steven& Marshall, William L.. Viral Infection : An Evolving Insight into the Signal Transduction Pathways Responsible for the Innate Immune Response. Advances in Virology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-448172
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448172
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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