Longitudinal Analysis of Tetanus- and Influenza-Specific IgG Antibodies in Myeloma Patients
المؤلفون المشاركون
Reinhard, Henrike
Luetkens, Tim
Cao, Yanran
Bokemeyer, Carsten
Templin, Julia
Haag, Friedrich
Sezer, Orhan
Bartels, Britta Marlen
Kobold, Sebastian
Atanackovic, Djordje
Kröger, Nicolaus
Lajmi, Nesrine
Hildebrandt, York
Bartels, Katrin
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Multiple myeloma (MM) and its therapies may induce a severely compromised humoral immunity.
We have performed a longitudinal analysis of IgG-antibody responses against influenza virus (FLU) and tetanus toxoid (TT) as surrogate markers for the B cell-mediated immunity in MM patients.
Methods.
1094 serum samples of 190 MM patients and samples from 100 healthy donors were analyzed by ELISA for FLU- and TT-specific antibodies.
Results.
MM patients evidenced lower levels of FLU- and TT-specific antibodies than healthy controls (P<0.001).
Immunoreactivity decreased with progressing disease and worsening clinical status.
Levels of FLU- and TT-specific antibodies increased shortly (0-6 months) after alloSCT (P<0.001), a time-period during which intravenous immunoglobulin (IVIG) is routinely applied.
Thereafter, antibody concentrations declined and remained suppressed for 3 years in the case of FLU-specific and for more than 5 years in the case of TT-specific antibodies.
Conclusions.
We found that MM is associated with a profound disease- and therapy-related immunosuppression, which is compensated for a few months after alloSCT, most likely by application of IVIG.
This and the differences regarding the recovery of anti-FLU and anti-TT antibody titers during the following years need to be taken into account for optimizing IVIG application and immunization after alloSCT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kobold, Sebastian& Luetkens, Tim& Bartels, Britta Marlen& Cao, Yanran& Hildebrandt, York& Sezer, Orhan…[et al.]. 2012. Longitudinal Analysis of Tetanus- and Influenza-Specific IgG Antibodies in Myeloma Patients. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-448329
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kobold, Sebastian…[et al.]. Longitudinal Analysis of Tetanus- and Influenza-Specific IgG Antibodies in Myeloma Patients. Clinical and Developmental Immunology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-448329
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kobold, Sebastian& Luetkens, Tim& Bartels, Britta Marlen& Cao, Yanran& Hildebrandt, York& Sezer, Orhan…[et al.]. Longitudinal Analysis of Tetanus- and Influenza-Specific IgG Antibodies in Myeloma Patients. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-448329
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448329
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر