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Role of Ryanodine Receptor Subtypes in Initiation and Formation of Calcium Sparks in Arterial Smooth Muscle : Comparison with Striated Muscle
المؤلفون المشاركون
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-12-08
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Calcium sparks represent local, rapid, and transient calcium release events from a cluster of ryanodine receptors (RyRs) in the sarcoplasmic reticulum.
In arterial smooth muscle cells (SMCs), calcium sparks activate calcium-dependent potassium channels causing decrease in the global intracellular [Ca2+] and oppose vasoconstriction.
This is in contrast to cardiac and skeletal muscle, where spatial and temporal summation of calcium sparks leads to global increases in intracellular [Ca2+] and myocyte contraction.
We summarize the present data on local RyR calcium signaling in arterial SMCs in comparison to striated muscle and muscle-specific differences in coupling between L-type calcium channels and RyRs.
Accordingly, arterial SMC Cav1.2 L-type channels regulate intracellular calcium stores content, which in turn modulates calcium efflux though RyRs.
Downregulation of RyR2 up to a certain degree is compensated by increased SR calcium content to normalize calcium sparks.
This indirect coupling between Cav1.2 and RyR in arterial SMCs is opposite to striated muscle, where triggering of calcium sparks is controlled by rapid and direct cross-talk between Cav1.1/Cav1.2 L-type channels and RyRs.
We discuss the role of RyR isoforms in initiation and formation of calcium sparks in SMCs and their possible molecular binding partners and regulators, which differ compared to striated muscle.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Essin, Kirill& Gollasch, Maik. 2009. Role of Ryanodine Receptor Subtypes in Initiation and Formation of Calcium Sparks in Arterial Smooth Muscle : Comparison with Striated Muscle. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-15.
https://search.emarefa.net/detail/BIM-448464
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Essin, Kirill& Gollasch, Maik. Role of Ryanodine Receptor Subtypes in Initiation and Formation of Calcium Sparks in Arterial Smooth Muscle : Comparison with Striated Muscle. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-15.
https://search.emarefa.net/detail/BIM-448464
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Essin, Kirill& Gollasch, Maik. Role of Ryanodine Receptor Subtypes in Initiation and Formation of Calcium Sparks in Arterial Smooth Muscle : Comparison with Striated Muscle. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-15.
https://search.emarefa.net/detail/BIM-448464
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448464
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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