Green Synthesis of Silver Nanoparticles : Structural Features and In Vivo and In Vitro Therapeutic Effects against Helicobacter pylori Induced Gastritis
المؤلفون المشاركون
Anwar, Farooq
Ali, Asghar
Khan, Safyan Akram
Amin, Muhammad
Hasan, Sara
Yaqoob, Aqdas
Shakir, Imran
Shahid, Shaukat Ali
Sajjad-ur-Rahman,
Hameed, Sadaf
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-06
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الموضوعات
الملخص EN
This study evaluates in vivo and in vitro anti-Helicobacter pylori (H.
pylori) efficacy of silver nanoparticles (Ag-NPs) prepared via a cost-effective green chemistry route wherein Peganum harmala L.
seeds extract was used as a reducing and capping agent.
The structural features, as elucidated by surface plasmon resonance spectrophotometry, transmission electron microscopy, and powder X-ray diffraction spectroscopy, revealed the Ag-NPs synthesized to be polydispersed in nature and spherical in shape with 5–40 nm size.
A typical Ag-NPs suspension (S5), with size being 15 nm, when tested in vitro against forty-two local isolates and two reference strains, showed a considerable anti-H.
pylori activity.
In case of in vivo trial against H.
pylori induced gastritis, after oral administration of 16 mg/kg body weight of S5 for seven days, a complete clearance was recorded in male albino rates.
In comparative time-killing kinetics, S5 exhibited dose- and time-dependent anti-H.
pylori activity that was almost similar to tetracycline and clarithromycin, less than amoxicillin, but higher than metronidazole.
Furthermore, S5 was found to be an equally effective anti-H.
pylori agent at low (≤4) and high pH with no drug resistance observed even up to 10 repeated exposures while a significant drug resistance was recorded for most of the standard drugs employed.
The present results revealed the potential of the synthesized Ag-NPs as safer bactericidal agents for the treatment of H.
pylori induced gastritis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Amin, Muhammad& Hameed, Sadaf& Ali, Asghar& Anwar, Farooq& Shahid, Shaukat Ali& Shakir, Imran…[et al.]. 2014. Green Synthesis of Silver Nanoparticles : Structural Features and In Vivo and In Vitro Therapeutic Effects against Helicobacter pylori Induced Gastritis. Bioinorganic Chemistry and Applications،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-448515
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Amin, Muhammad…[et al.]. Green Synthesis of Silver Nanoparticles : Structural Features and In Vivo and In Vitro Therapeutic Effects against Helicobacter pylori Induced Gastritis. Bioinorganic Chemistry and Applications No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-448515
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Amin, Muhammad& Hameed, Sadaf& Ali, Asghar& Anwar, Farooq& Shahid, Shaukat Ali& Shakir, Imran…[et al.]. Green Synthesis of Silver Nanoparticles : Structural Features and In Vivo and In Vitro Therapeutic Effects against Helicobacter pylori Induced Gastritis. Bioinorganic Chemistry and Applications. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-448515
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448515
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر