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Pharmacogenomics in Children : Advantages and Challenges of Next Generation Sequencing Applications
المؤلفون المشاركون
Vanakker, Olivier M.
De Paepe, Anne
المصدر
International Journal of Pediatrics
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Pharmacogenetics is considered as a prime example of how personalized medicine nowadays can be put into practice.
However, genotyping to guide pharmacological treatment is relatively uncommon in the routine clinical practice.
Several reasons can be found why the application of pharmacogenetics is less than initially anticipated, which include the contradictory results obtained for certain variants and the lack of guidelines for clinical implementation.
However, more reproducible results are being generated, and efforts have been made to establish working groups focussing on evidence-based clinical guidelines.
For another pharmacogenetic hurdle, the speed by which a pharmacogenetic profile for a certain drug can be obtained in an individual patient, there has been a revolution in molecular genetics through the introduction of next generation sequencing (NGS), making it possible to sequence a large number of genes up to the complete genome in a single reaction.
Besides the enthusiasm due to the tremendous increase of our sequencing capacities, several considerations need to be made regarding quality and interpretation of the sequence data as well as ethical aspects of this technology.
This paper will focus on the different NGS applications that may be useful for pharmacogenomics in children and the challenges that they bring on.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vanakker, Olivier M.& De Paepe, Anne. 2013. Pharmacogenomics in Children : Advantages and Challenges of Next Generation Sequencing Applications. International Journal of Pediatrics،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-448575
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vanakker, Olivier M.& De Paepe, Anne. Pharmacogenomics in Children : Advantages and Challenges of Next Generation Sequencing Applications. International Journal of Pediatrics No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-448575
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vanakker, Olivier M.& De Paepe, Anne. Pharmacogenomics in Children : Advantages and Challenges of Next Generation Sequencing Applications. International Journal of Pediatrics. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-448575
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448575
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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