Electroacupuncture-Induced Neuroprotection against Cerebral Ischemia in Rats : Role of the Dopamine D2 Receptor
المؤلفون المشاركون
Li, Li-Hui
Ge, Lin-Bao
Li, Ming-Zhe
Liu, Cheng-Yong
Zhao, Dan
Li, Chang-Zhi
Xu, Ming-Shu
Chen, Chun-Yan
Xu, Jia
Zhang, Shu-Jing
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Cerebral ischemia is known to produce brain damage and related behavioural deficits, including memory deficits and motor disorders.
Evidence shows that EA significantly promotes recovery of neurological function and thus improves quality of life.
Objective.
Evidence exists for the involvement of catecholamines in human neuroplasticity.
A better understanding of dopaminergic (DAergic) modulation in this process will be important.
Methods.
A total of 72 adult male Sprague-Dawley (SD) rats were divided into 6 groups: normal, model, EA, spiperone group, EA + spiperone group, and pergolide.
The middle cerebral artery occlusion (MCAO) model was used in all 6 groups except the normal group.
A behavioural assessment was conducted at 1, 3, 5, and 7 days after MCAO.
The percent of brain infarct area was also determined 7 days after MCAO.
Tyrosine hydroxylase (TH) and growth-associated protein 43 (GAP-43) fluorescence double labeling was performed in the striatum.
Results.
In this study, we found that EA at Fengchi (GB20) acupoints resulted in marked improvements based on a behavioural assessment.
Both TTC staining and GAP-43 immunofluorescence labeling results showed that EA treatment reduced ischemia injury and promoted neuroplasticity compared with the model group.
The D2R-selective agonist, pergolide, showed similar results, but these results were reversed by the D2R-selective antagonist, spiperone.
We also found that there were more colocalization and expression of GAP-43 and TH in the EA and pergolide groups than those in the other groups.
Conclusion.
These results suggest that the neuroplasticity induced by EA was mediated by D2 autoreceptors in DAergic neurons.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Ming-Shu& Zhang, Shu-Jing& Zhao, Dan& Liu, Cheng-Yong& Li, Chang-Zhi& Chen, Chun-Yan…[et al.]. 2013. Electroacupuncture-Induced Neuroprotection against Cerebral Ischemia in Rats : Role of the Dopamine D2 Receptor. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-448682
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Ming-Shu…[et al.]. Electroacupuncture-Induced Neuroprotection against Cerebral Ischemia in Rats : Role of the Dopamine D2 Receptor. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-448682
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Ming-Shu& Zhang, Shu-Jing& Zhao, Dan& Liu, Cheng-Yong& Li, Chang-Zhi& Chen, Chun-Yan…[et al.]. Electroacupuncture-Induced Neuroprotection against Cerebral Ischemia in Rats : Role of the Dopamine D2 Receptor. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-448682
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448682
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر