Simulation of Exercise-Induced Syncope in a Heart Model with Severe Aortic Valve Stenosis
المؤلفون المشاركون
Kordaš, Marjan
Ribarič, Samo
Sever, Matjaž
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Severe aortic valve stenosis (AVS) can cause an exercise-induced reflex syncope (RS).
The precise mechanism of this syncope is not known.
The changes in hemodynamics are variable, including arrhythmias and myocardial ischemia, and one of the few consistent changes is a sudden fall in systemic and pulmonary arterial pressures (suggesting a reduced vascular resistance) followed by a decline in heart rate.
The contribution of the cardioinhibitory and vasodepressor components of the RS to hemodynamics was evaluated by a computer model.
This lumped-parameter computer simulation was based on equivalent electronic circuits (EECs) that reflect the hemodynamic conditions of a heart with severe AVS and a concomitantly decreased contractility as a long-term detrimental consequence of compensatory left ventricular hypertrophy.
In addition, the EECs model simulated the resetting of the sympathetic nervous tone in the heart and systemic circuit during exercise and exercise-induced syncope, the fluctuating intra-thoracic pressure during respiration, and the passive relaxation of ventricle during diastole.
The results of this simulation were consistent with the published case reports of exertional syncope in patients with AVS.
The value of the EEC model is its ability to quantify the effect of a selective and gradable change in heart rate, ventricular contractility, or systemic vascular resistance on the hemodynamics during an exertional syncope in patients with severe AVS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sever, Matjaž& Ribarič, Samo& Kordaš, Marjan. 2012. Simulation of Exercise-Induced Syncope in a Heart Model with Severe Aortic Valve Stenosis. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-448751
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sever, Matjaž…[et al.]. Simulation of Exercise-Induced Syncope in a Heart Model with Severe Aortic Valve Stenosis. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-448751
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sever, Matjaž& Ribarič, Samo& Kordaš, Marjan. Simulation of Exercise-Induced Syncope in a Heart Model with Severe Aortic Valve Stenosis. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-448751
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448751
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر