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A Novel Platelet Activating Factor Receptor Antagonist Reduces Cell Infiltration and Expression of Inflammatory Mediators in Mice Exposed to Desiccating Conditions after PRK
المؤلفون المشاركون
He, Jiucheng
Li, Na
Bazan, Nicolas G.
Bazan, Haydee E. P.
Esquenazi, Salomon
Esquenazi, Isi
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-12-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
To study the contribution of a novel PAF receptor antagonist LAU-0901 in the modulation of the increased inflammatory response in mice exposed to dessicating conditions (DE) after PRK.
Methods.
Eighty 13-14 week old female Balb/C mice were used.
They were divided into two groups: One group was treated with LAU-0901 topical drops.
The other group was treated with vehicle.
In each group ten mice served as controls and ten were placed in DE.
The other twenty mice underwent bilateral PRK and were divided in two additional groups: ten mice remained under normal conditions (NC) and the other ten were exposed to DE.
After 1 week all animals underwent in vivo confocal microscopy, immunostaining and western blotting analysis.
Results.
Confocal microscopy showed an increased number of reflective structures in the corneal epithelium after PRK and exposure to DE in eyes treated with vehicle as compared to eyes treated with LAU-0901.
Significant decrease of COX-2 and Arginase I expression and reduced alpha SMA cells was observed after PRK and exposure to DE in eyes treated with LAU-0901.
Discussion: Exposure of mice to a DE after PRK increases the epithelial turnover rate.
PAF is involved in the inflammatory cell infiltration and expression of inflammatory cytokines that follow PRK under DE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Esquenazi, Salomon& He, Jiucheng& Li, Na& Bazan, Nicolas G.& Esquenazi, Isi& Bazan, Haydee E. P.. 2009. A Novel Platelet Activating Factor Receptor Antagonist Reduces Cell Infiltration and Expression of Inflammatory Mediators in Mice Exposed to Desiccating Conditions after PRK. Clinical and Developmental Immunology،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-448772
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Esquenazi, Salomon…[et al.]. A Novel Platelet Activating Factor Receptor Antagonist Reduces Cell Infiltration and Expression of Inflammatory Mediators in Mice Exposed to Desiccating Conditions after PRK. Clinical and Developmental Immunology No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-448772
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Esquenazi, Salomon& He, Jiucheng& Li, Na& Bazan, Nicolas G.& Esquenazi, Isi& Bazan, Haydee E. P.. A Novel Platelet Activating Factor Receptor Antagonist Reduces Cell Infiltration and Expression of Inflammatory Mediators in Mice Exposed to Desiccating Conditions after PRK. Clinical and Developmental Immunology. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-448772
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448772
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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