Antilipogenic and Anti-Inflammatory Activities of Codonopsis lanceolata in Mice Hepatic Tissues after Chronic Ethanol Feeding

المؤلفون المشاركون

Koo, Yun-Chang
Cha, Areum
Choi, Youngshim
Park, Taesun
Sung, Mi-Kyung
Lee, Kwang-Won
Jin, Yoojeong

المصدر

Journal of Biomedicine and Biotechnology

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-10-12

دولة النشر

مصر

عدد الصفحات

13

التخصصات الرئيسية

الطب البشري

الملخص EN

This study evaluated the antilipogenic and anti-inflammatory effects of Codonopsis lanceolata (C.

lanceolata) root extract in mice with alcohol-induced fatty liver and elucidated its underlying molecular mechanisms.

Ethanol was introduced into the liquid diet by mixing it with distilled water at 5% (wt/v), providing 36% of the energy, for nine weeks.

Among the three different fractions prepared from the C.

lanceolata root, the C.

lanceolata methanol extract (CME) exhibited the most remarkable attenuation of alcohol-induced fatty liver with respect to various parameters such as hepatic free fatty acid concentration, body weight loss, and hepatic accumulations of triglyceride and cholesterol.

The hepatic gene and protein expression levels were analysed via RT-PCR and Western blotting, respectively.

CME feeding significantly restored the ethanol-induced downregulation of the adiponectin receptor (adipoR) 1 and of adipoR2, along with their downstream molecules.

Furthermore, the study data showed that CME feeding dramatically reversed ethanol-induced hepatic upregulation of toll-like receptor- (TLR-) mediated signaling cascade molecules.

These results indicate that the beneficial effects of CME against alcoholic fatty livers of mice appear to be with adenosine- and adiponectin-mediated regulation of hepatic steatosis and TLR-mediated modulation of hepatic proinflammatory responses.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Cha, Areum& Choi, Youngshim& Jin, Yoojeong& Sung, Mi-Kyung& Koo, Yun-Chang& Lee, Kwang-Won…[et al.]. 2011. Antilipogenic and Anti-Inflammatory Activities of Codonopsis lanceolata in Mice Hepatic Tissues after Chronic Ethanol Feeding. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-449027

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Cha, Areum…[et al.]. Antilipogenic and Anti-Inflammatory Activities of Codonopsis lanceolata in Mice Hepatic Tissues after Chronic Ethanol Feeding. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-449027

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Cha, Areum& Choi, Youngshim& Jin, Yoojeong& Sung, Mi-Kyung& Koo, Yun-Chang& Lee, Kwang-Won…[et al.]. Antilipogenic and Anti-Inflammatory Activities of Codonopsis lanceolata in Mice Hepatic Tissues after Chronic Ethanol Feeding. Journal of Biomedicine and Biotechnology. 2011. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-449027

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-449027