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Expansion and Activation Kinetics of Immune Cells during Early Phase of GVHD in Mouse Model Based on Chemotherapy Conditioning
المؤلفون المشاركون
Hassan, Moustapha
Rozell, Bjorn
Hassan, Zuzana
al-Hashmi, Suleiman
Concha, Hernan
Lundmark, Carin
Grönvik, Kjell-Olov
Abedi-Valugerdi, Manuchehr
Sadeghi, Behnam
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-12-21
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
In the present paper, we have investigated early pathophysiological events in graft-versus-host disease (GVHD), a major complication to hematopoietic stem cell transplantation (HSCT).
BLLB/c female mice conditioned with busulfan/cyclophosphamide (Bu-Cy) were transplanted with allogeneic male C57BL/6.
Control group consisted of syngeneic transplanted Balb/c mice.
In allogeneic settings, significant expansion and maturation of donor dendritic cells (DCs) were observed at day +3, while donor T-cells CD8+ were increased at day +5 (230%) compared to syngeneic HSCT.
Highest levels of inflammatory cytokines IL-2, IFN-gamma, and TNF-alfa at day +5 matched T-cell activation.
Concomitantly naïve T-cells gain effecr-memory phenotype and migrated from spleen to peripheral lymphoid organs.
Thus, in the very early phase of GHVD following Bu-Cy conditioning donor, DCs play an important role in the activation of donor T cells.
Subsequently, donor naïve T-cells gain effector-memory phenotype and initiate GVHD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sadeghi, Behnam& al-Hashmi, Suleiman& Hassan, Zuzana& Rozell, Bjorn& Concha, Hernan& Lundmark, Carin…[et al.]. 2010. Expansion and Activation Kinetics of Immune Cells during Early Phase of GVHD in Mouse Model Based on Chemotherapy Conditioning. Clinical and Developmental Immunology،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-449165
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sadeghi, Behnam…[et al.]. Expansion and Activation Kinetics of Immune Cells during Early Phase of GVHD in Mouse Model Based on Chemotherapy Conditioning. Clinical and Developmental Immunology No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-449165
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sadeghi, Behnam& al-Hashmi, Suleiman& Hassan, Zuzana& Rozell, Bjorn& Concha, Hernan& Lundmark, Carin…[et al.]. Expansion and Activation Kinetics of Immune Cells during Early Phase of GVHD in Mouse Model Based on Chemotherapy Conditioning. Clinical and Developmental Immunology. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-449165
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449165
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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