Effect and Safety of Mycophenolate Mofetil or Sodium in Systemic Sclerosis-Associated Interstitial Lung Disease : A Meta-Analysis
المؤلفون المشاركون
Bouros, Demosthenes
Ntolios, Paschalis
Tzouvelekis, Argyris
Zacharis, George
Bouros, Evangelos
Galanopoulos, Nikolaos
Kolios, George
Oikonomou, Anastasia
Koulelidis, Andreas
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Interstitial lung disease (ILD) is the most common complication of systemic sclerosis (SSc) with treatment ineffective.
Objective: The aim of this meta-analysis was to provide an estimate of the safety and efficacy profile of Mycophenolate Mofetil (MMF) or sodium (MMS) in SSc-ILD patients.
Materials and Methods.
All studies were reviewed systematically.
The main end-points were safety and efficacy profile as estimated by forced vital capacity (FVC)% and diffusion capacity of the lung for carbon monoxide (DLCO)% of the predicted normal value (%pred.) before and after treatment in patients with SSc-ILD.
Quality assessment and data extraction were performed independently by two reviewers.
Results.
Seventeen studies were reviewed systematically.
Six studies, one prospective, were eligible for analysis encompassing 69 patients, including 10 subjects from our, yet unpublished, retrospective study.
There was no statistically significant difference in both efficacy outcomes of interest, including FVC% pred.
(weighted mean difference 1.48, 95% confidence interval (CI): −2.77 to 5.72, P=0.49) and DLCO % pred.
(weighted mean difference −0.83, 95% CI: −4.75 to 3.09, P=0.93).
No cases of clinically significant side effects were documented.
Conclusions.
Meta-analysis data suggest that MMF is a safe therapeutic modality which was associated with functional stabilization in patients with SSc-ILD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tzouvelekis, Argyris& Galanopoulos, Nikolaos& Bouros, Evangelos& Kolios, George& Zacharis, George& Ntolios, Paschalis…[et al.]. 2012. Effect and Safety of Mycophenolate Mofetil or Sodium in Systemic Sclerosis-Associated Interstitial Lung Disease : A Meta-Analysis. Pulmonary Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-449223
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tzouvelekis, Argyris…[et al.]. Effect and Safety of Mycophenolate Mofetil or Sodium in Systemic Sclerosis-Associated Interstitial Lung Disease : A Meta-Analysis. Pulmonary Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-449223
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tzouvelekis, Argyris& Galanopoulos, Nikolaos& Bouros, Evangelos& Kolios, George& Zacharis, George& Ntolios, Paschalis…[et al.]. Effect and Safety of Mycophenolate Mofetil or Sodium in Systemic Sclerosis-Associated Interstitial Lung Disease : A Meta-Analysis. Pulmonary Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-449223
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449223
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر