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Combined Contribution of Endothelial Relaxing Autacoides in the Rat Femoral Artery Response to CPCA : An Adenosine A2 Receptor Agonist
المؤلفون المشاركون
Janković, Radmila
Topalović, Mirko
Radenković, Miroslav
Stojiljković, Milica
Stojanović, Marko
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
We examined the contribution of endothelial relaxing factors and potassium channels in actions of CPCA, potent adenosine A2 receptor agonist, on isolated intact male rat femoral artery (FA).
CPCA produced concentration-dependent relaxation of FA, which was notably, but not completely, reduced after endothelial denudation.
DPCPX, A1 receptor antagonist, had no significant effect, while SCH 58261 (A2A receptor antagonist) notably reduced CPCA-evoked effect.
Pharmacological inhibition of nitric oxide synthase or cyclooxygenase comparably reduced CPCA-evoked action, still in a lesser degree than after denudation.
In the presence of buffer with high K+ (100 mM), CPCA-produced relaxations were almost abolished.
TEA (nonselective KCa blocker), glibenclamide (KATP blocker), Ba++ (KIR blocker), or ouabain (Na+/K+-ATPase inhibitor) did not change CPCA-induced relaxation.
Concentration-response curve for CPCA was significantly shifted to the right after the incubation of apamin (SK channel blocker).
CPCA produced concentration-dependent relaxation of FA that was partly dependent on endothelial cells.
Endothelium-related portion of CPCA-elicited effect was mediated by combined action of endothelial NO, prostacyclin, and EDHF after activation of endothelial A2A receptors.
Small conductance KCa channels were involved in this action.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Radenković, Miroslav& Stojanović, Marko& Janković, Radmila& Topalović, Mirko& Stojiljković, Milica. 2012. Combined Contribution of Endothelial Relaxing Autacoides in the Rat Femoral Artery Response to CPCA : An Adenosine A2 Receptor Agonist. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-449242
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Radenković, Miroslav…[et al.]. Combined Contribution of Endothelial Relaxing Autacoides in the Rat Femoral Artery Response to CPCA : An Adenosine A2 Receptor Agonist. The Scientific World Journal No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-449242
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Radenković, Miroslav& Stojanović, Marko& Janković, Radmila& Topalović, Mirko& Stojiljković, Milica. Combined Contribution of Endothelial Relaxing Autacoides in the Rat Femoral Artery Response to CPCA : An Adenosine A2 Receptor Agonist. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-449242
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449242
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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