Elevated Red Blood Cell Distribution Width as a Simple Prognostic Factor in Patients with Symptomatic Multiple Myeloma
المؤلفون المشاركون
Kong, Sun-Young
Eom, Hyeon-Seok
Shim, Hyoeun
Youn, Hye Sun
Lee, Hyewon
Kim, Hyun Ju
Lee, Sangeun
Sohn, Ji Yeon
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-21
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Red blood cell distribution width (RDW) is a parameter reported in complete blood cell count tests, and has been reported as an inflammatory biomarker.
Multiple myeloma (MM) is known to be associated with inflammatory microenvironments.
However, the importance of RDW has been seldom studied in MM.
For this study, 146 symptomatic myeloma patients with available RDW at diagnosis were retrospectively reviewed, and their characteristics were compared between two groups, those with high (>14.5%) and normal (≤14.5%) RDW.
RDW was correlated to hemoglobin, MM stage, β2-microglobulin, M-protein, bone marrow plasma cells, and cellularity (P<0.001).
During induction, overall response rates of the two groups were similar (P=0.195); however, complete response rate was higher in the normal-RDW group than it was in the high-RDW group (P=0.005).
With a median follow-up of 47 months, the normal-RDW group showed better progression-free survival (PFS) (24.2 versus 17.0 months, P=0.029) compared to the high-RDW group.
Overall survival was not different according to the RDW level (P=0.236).
In multivariate analysis, elevated RDW at diagnosis was a poor prognostic factor for PFS (HR 3.21, 95% CI 1.24–8.32) after adjustment with other myeloma-related prognostic factors.
RDW would be a simple and immediately available biomarker of symptomatic MM, reflecting the systemic inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Hyewon& Kong, Sun-Young& Sohn, Ji Yeon& Shim, Hyoeun& Youn, Hye Sun& Lee, Sangeun…[et al.]. 2014. Elevated Red Blood Cell Distribution Width as a Simple Prognostic Factor in Patients with Symptomatic Multiple Myeloma. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-449323
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Hyewon…[et al.]. Elevated Red Blood Cell Distribution Width as a Simple Prognostic Factor in Patients with Symptomatic Multiple Myeloma. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-449323
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Hyewon& Kong, Sun-Young& Sohn, Ji Yeon& Shim, Hyoeun& Youn, Hye Sun& Lee, Sangeun…[et al.]. Elevated Red Blood Cell Distribution Width as a Simple Prognostic Factor in Patients with Symptomatic Multiple Myeloma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-449323
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449323
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر