![](/images/graphics-bg.png)
Honokiol Eliminates Human Oral Cancer Stem-Like Cells Accompanied with Suppression of Wntβ-Catenin Signaling and Apoptosis Induction
المؤلفون المشاركون
Whang-Peng, Jacqueline
Chuang, Shuang-En
Yeh, Chi-Tai
Shih, Ping-Hsiao
Lai, Tung-Yuan
Yao, Chih-Jung
Lai, Gi-Ming
Lai, Ming-Tang
Chao, Wan-Ju
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-10
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Honokiol, an active compound of Magnolia officinalis, exerted many anticancer effects on various types of cancer cells.
We explored its effects on the elimination of cancer stem-like side population (SP) cells in human oral squamous cell carcinoma SAS cells.
The sorted SP cells possessed much higher expression of stemness genes, such as ABCG2, ABCC5, EpCAM, OCT-4, CD133, CD44, and β-catenin, and more clonogenicity as compared with the Non-SP cells.
After 48 h of treatment, honokiol dose dependently reduced the proportion of SP from 2.53% to 0.09%.
Apoptosis of honokiol-treated SP cells was evidenced by increased annexin V staining and cleaved caspase-3 as well as decreased Survivin and Bcl-2.
Mechanistically, honokiol inhibited the CD44 and Wnt/β-catenin signaling of SP cells.
The Wnt signaling transducers such as β-catenin and TCF-4 were decreased in honokiol-treated SP cells, while the β-catenin degradation promoting kinase GSK-3α/β was increased.
Consistently, the protein levels of β-catenin downstream targets such as c-Myc and Cyclin D1 were also downregulated.
Furthermore, the β-catenin-related EMT markers such as Slug and Snail were markedly suppressed by honokiol.
Our findings indicate honokiol may be able to eliminate oral cancer stem cells through apoptosis induction, suppression of Wnt/β-catenin signaling, and inhibition of EMT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yao, Chih-Jung& Lai, Gi-Ming& Yeh, Chi-Tai& Lai, Ming-Tang& Shih, Ping-Hsiao& Chao, Wan-Ju…[et al.]. 2013. Honokiol Eliminates Human Oral Cancer Stem-Like Cells Accompanied with Suppression of Wntβ-Catenin Signaling and Apoptosis Induction. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-449377
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yao, Chih-Jung…[et al.]. Honokiol Eliminates Human Oral Cancer Stem-Like Cells Accompanied with Suppression of Wntβ-Catenin Signaling and Apoptosis Induction. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-449377
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yao, Chih-Jung& Lai, Gi-Ming& Yeh, Chi-Tai& Lai, Ming-Tang& Shih, Ping-Hsiao& Chao, Wan-Ju…[et al.]. Honokiol Eliminates Human Oral Cancer Stem-Like Cells Accompanied with Suppression of Wntβ-Catenin Signaling and Apoptosis Induction. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-449377
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449377
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)