In Silico Nanodosimetry : New Insights into Nontargeted Biological Responses to Radiation
المؤلفون المشاركون
Kuncic, Zdenka
McNamara, Aimee L.
Guatelli, Susanna
Domanova, Westa
Byrne, Hilary L.
Incerti, Sébastien
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The long-held view that radiation-induced biological damage must be initiated in the cell nucleus, either on or near DNA itself, is being confronted by mounting evidence to suggest otherwise.
While the efficacy of cell death may be determined by radiation damage to nuclear DNA, a plethora of less deterministic biological responses has been observed when DNA is not targeted.
These so-called nontargeted responses cannot be understood in the framework of DNA-centric radiobiological models; what is needed are new physically motivated models that address the damage-sensing signalling pathways triggered by the production of reactive free radicals.
To this end, we have conducted a series of in silico experiments aimed at elucidating the underlying physical processes responsible for nontargeted biological responses to radiation.
Our simulation studies implement new results on very low-energy electromagnetic interactions in liquid water (applicable down to nanoscales) and we also consider a realistic simulation of extranuclear microbeam irradiation of a cell.
Our results support the idea that organelles with important functional roles, such as mitochondria and lysosomes, as well as membranes, are viable targets for ionizations and excitations, and their chemical composition and density are critical to determining the free radical yield and ensuing biological responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kuncic, Zdenka& Byrne, Hilary L.& McNamara, Aimee L.& Guatelli, Susanna& Domanova, Westa& Incerti, Sébastien. 2012. In Silico Nanodosimetry : New Insights into Nontargeted Biological Responses to Radiation. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-449491
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kuncic, Zdenka…[et al.]. In Silico Nanodosimetry : New Insights into Nontargeted Biological Responses to Radiation. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-449491
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kuncic, Zdenka& Byrne, Hilary L.& McNamara, Aimee L.& Guatelli, Susanna& Domanova, Westa& Incerti, Sébastien. In Silico Nanodosimetry : New Insights into Nontargeted Biological Responses to Radiation. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-449491
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449491
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر