A Systematic, Integrated Study on the Neuroprotective Effects of Hydroxysafflor Yellow A Revealed by H1 NMR-Based Metabonomics and the NF-κB Pathway

المؤلفون المشاركون

Chen, Tingting
Li, Jianbei
Liu, Yuanyan
Ma, Shuanggang
Qu, Jing
Lian, Zeqin
Chen, Xianhong
Wang, Yinghong
Yu, Shishan
Zhu, Haibo

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-04-22

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الطب البشري

الملخص EN

Hydroxysafflor yellow A (HSYA) is the main active component of the Chinese herb Carthamus tinctorius L..

Purified HSYA is used as a neuroprotective agent to prevent cerebral ischemia.

Injectable safflor yellow (50 mg, containing 35 mg HSYA) is widely used to treat patients with ischemic cardiocerebrovascular disease.

However, it is unknown how HSYA exerts a protective effect on cerebral ischemia at the molecular level.

A systematical integrated study, including histopathological examination, neurological evaluation, blood-brain barrier (BBB), metabonomics, and the nuclear factor-κB (NF-κB) pathway, was applied to elucidate the pathophysiological mechanisms of HSYA neuroprotection at the molecular level.

HSYA could travel across the BBB, significantly reducing the infarct volume and improving the neurological functions of rats with ischemia.

Treatment with HSYA could lead to relative corrections of the impaired metabolic pathways through energy metabolism disruption, excitatory amino acid toxicity, oxidative stress, and membrane disruption revealed by 1H NMR-based metabonomics.

Meanwhile, HSYA treatment inhibits the NF-κB pathway via suppressing proinflammatory cytokine expression and p65 translocation and binding activity while upregulating an anti-inflammatory cytokine.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Liu, Yuanyan& Lian, Zeqin& Zhu, Haibo& Wang, Yinghong& Yu, Shishan& Chen, Tingting…[et al.]. 2013. A Systematic, Integrated Study on the Neuroprotective Effects of Hydroxysafflor Yellow A Revealed by H1 NMR-Based Metabonomics and the NF-κB Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-449503

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Liu, Yuanyan…[et al.]. A Systematic, Integrated Study on the Neuroprotective Effects of Hydroxysafflor Yellow A Revealed by H1 NMR-Based Metabonomics and the NF-κB Pathway. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-449503

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Liu, Yuanyan& Lian, Zeqin& Zhu, Haibo& Wang, Yinghong& Yu, Shishan& Chen, Tingting…[et al.]. A Systematic, Integrated Study on the Neuroprotective Effects of Hydroxysafflor Yellow A Revealed by H1 NMR-Based Metabonomics and the NF-κB Pathway. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-449503

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-449503