Single Nucleotide Polymorphisms in Selected Apoptotic Genes and BPDE-Induced Apoptotic Capacity in Apparently Normal Primary Lymphocytes : A Genotype-Phenotype Correlation Analysis
المؤلفون المشاركون
Wei, Qingyi
Chen, Kexin
Spitz, Margaret R.
Sturgis, Erich M.
Hu, Zhibin
Li, Chunying
Wang, Li-E
المصدر
Journal of Cancer Epidemiology
العدد
المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2008-10-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Apoptotic capacity (AC) in primary lymphocytes may be a marker for cancer susceptibility, and functional single nucleotide polymorphisms (SNPs) in genes involved in apoptotic pathways may modulate cellular AC in response to DNA damage.
To further examine the correlation between apoptotic genotypes and phenotype, we genotyped 14 published SNPs in 11 apoptosis-related genes (i.e., p53, Bcl-2, BAX, CASP9, DR4, Fas, FasL, CASP8, CASP10, CASP3, and CASP7) and assessed the AC in response to benzo[a]pyrene-7,8-9,10-diol epoxide (BPDE) in cultured primary lymphocytes from 172 cancer-free subjects.
We found that among these 14 SNPs, R72P, intron 3 16-bp del/ins, and intron 6 G>A in p53, −938C>A in Bcl-2, and I522L in CASP10 were significant predictors of the BPDE-induced lymphocytic AC in single-locus analysis.
In the combined analysis of the three p53 variants, we found that the individuals with the diplotypes carrying 0-1 copy of the common p53 R-del-G haplotype had higher AC values compared to other genotypes.
Although the study size may not have the statistical power to detect the role of other SNPs in AC, our findings suggest that some SNPs in genes involved in the intrinsic apoptotic pathway may modulate lymphocytic AC in response to BPDE exposure in the general population.
Larger studies are needed to validate these findings for further studying individual susceptibility to cancer and other apoptosis-related diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Zhibin& Li, Chunying& Chen, Kexin& Wang, Li-E& Sturgis, Erich M.& Spitz, Margaret R.…[et al.]. 2008. Single Nucleotide Polymorphisms in Selected Apoptotic Genes and BPDE-Induced Apoptotic Capacity in Apparently Normal Primary Lymphocytes : A Genotype-Phenotype Correlation Analysis. Journal of Cancer Epidemiology،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-449550
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Zhibin…[et al.]. Single Nucleotide Polymorphisms in Selected Apoptotic Genes and BPDE-Induced Apoptotic Capacity in Apparently Normal Primary Lymphocytes : A Genotype-Phenotype Correlation Analysis. Journal of Cancer Epidemiology No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-449550
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Zhibin& Li, Chunying& Chen, Kexin& Wang, Li-E& Sturgis, Erich M.& Spitz, Margaret R.…[et al.]. Single Nucleotide Polymorphisms in Selected Apoptotic Genes and BPDE-Induced Apoptotic Capacity in Apparently Normal Primary Lymphocytes : A Genotype-Phenotype Correlation Analysis. Journal of Cancer Epidemiology. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-449550
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449550
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر