Inhibition of Aldose Reductase by Gentiana lutea Extracts
المؤلفون المشاركون
Reddy, Geereddy Bhanuprakash
Akileshwari, Chandrasekhar
Joksić, Gordana
Muthenna, Puppala
Nastasijević, Branislav
Petrash, J. Mark
المصدر
Experimental Diabetes Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Accumulation of intracellular sorbitol due to increased aldose reductase (ALR2) activity has been implicated in the development of various secondary complications of diabetes.
Thus, ALR2 inhibition could be an effective strategy in the prevention or delay of certain diabetic complications.
Gentiana lutea grows naturally in the central and southern areas of Europe.
Its roots are commonly consumed as a beverage in some European countries and are also known to have medicinal properties.
The water, ethanol, methanol, and ether extracts of the roots of G.
lutea were subjected to in vitro bioassay to evaluate their inhibitory activity on the ALR2.
While the ether and methanol extracts showed greater inhibitory activities against both rat lens and human ALR2, the water and ethanol extracts showed moderate inhibitory activities.
Moreover, the ether and methanol extracts of G.
lutea roots significantly and dose-dependently inhibited sorbitol accumulation in human erythrocytes under high glucose conditions.
Molecular docking studies with the constituents commonly present in the roots of G.
lutea indicate that a secoiridoid glycoside, amarogentin, may be a potential inhibitor of ALR2.
This is the first paper that shows G.
lutea extracts exhibit inhibitory activity towards ALR2 and these results suggest that Gentiana or its constituents might be useful to prevent or treat diabetic complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Akileshwari, Chandrasekhar& Muthenna, Puppala& Nastasijević, Branislav& Joksić, Gordana& Petrash, J. Mark& Reddy, Geereddy Bhanuprakash. 2012. Inhibition of Aldose Reductase by Gentiana lutea Extracts. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-449560
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Akileshwari, Chandrasekhar…[et al.]. Inhibition of Aldose Reductase by Gentiana lutea Extracts. Experimental Diabetes Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-449560
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Akileshwari, Chandrasekhar& Muthenna, Puppala& Nastasijević, Branislav& Joksić, Gordana& Petrash, J. Mark& Reddy, Geereddy Bhanuprakash. Inhibition of Aldose Reductase by Gentiana lutea Extracts. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-449560
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449560
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر