The Effect of Specific Immunotherapy on Natural Killer T cells in Peripheral Blood of House Dust Mite-Sensitized Children with Asthma
المؤلفون المشاركون
Wei, Chen
Chen, Li
Lan-fang, Cao
Yan-ming, Lu
Ya-qin, Li
Wen-ming, Zhang
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-13
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
To investigate the effects of specific immunotherapy on the NKT cells in peripheral blood and the ability of NKT cells to proliferate in response to alpha-galactosylceramide (alpha-GalCer) in house-dust-mite- (HDM-) sensitized asthma children, peripheral blood mononuclear cells were isolated from 42 asthmatic children, of whom 24 were on specific immunotherapy (SIT) for more than a year and 20 were healthy.
Compared with control group, the ratio of peripheral blood NKT and CD4+NKT cells was significantly decreased (P<0.01) and was elevated in SIT asthma group (P<0.05), respectively, but it was still less than the normal control group (P<0.01).
The level of IL-4 in serum secreted by NKT cells in asthma group was significantly higher than that of control group (P<0.01), particularly apparent after 72 hours.
The level of IL-4 in SIT group decreased significantly (P<0.01).
The level of IL-10 in serum secreted by NKT cells in asthma group was decreased significantly than that of the control group (P<0.01) especially in 48 hours, while that of SIT group was increased significantly (P<0.01).
These results suggest that the pathogenesis of asthma may be related to the ratio and dysfunction of NKT and CD4+NKT cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yan-ming, Lu& Lan-fang, Cao& Chen, Li& Ya-qin, Li& Wei, Chen& Wen-ming, Zhang. 2012. The Effect of Specific Immunotherapy on Natural Killer T cells in Peripheral Blood of House Dust Mite-Sensitized Children with Asthma. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-449591
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yan-ming, Lu…[et al.]. The Effect of Specific Immunotherapy on Natural Killer T cells in Peripheral Blood of House Dust Mite-Sensitized Children with Asthma. Clinical and Developmental Immunology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-449591
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yan-ming, Lu& Lan-fang, Cao& Chen, Li& Ya-qin, Li& Wei, Chen& Wen-ming, Zhang. The Effect of Specific Immunotherapy on Natural Killer T cells in Peripheral Blood of House Dust Mite-Sensitized Children with Asthma. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-449591
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449591
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر