Effects of Neoadjuvant IntraperitonealSystemic Chemotherapy (Bidirectional Chemotherapy) for the Treatment of Patients with Peritoneal Metastasis from Gastric Cancer
المؤلفون المشاركون
Yonemura, Yutaka
Elnemr, Ayman
Mizumoto, Akiyoshi
Miura, Masahiro
Li, Yan
Ishibashi, Haruaki
Endou, Yoshio
المصدر
International Journal of Surgical Oncology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Novel multidisciplinary treatment combined with neoadjuvant intraperitoneal-systemic chemotherapy protocol (NIPS) and peritonectomy was developed.
Ninety-six patients were enrolled.
Peritoneal wash cytology was performed before and after NIPS through a port system.
Patients were treated with 60 mg/m2 of oral S-1 for 21 days, followed by a 1-week rest.
On days 1, 8, and 15, 30 mg/m2 of Taxotere and 30 mg/m2 of cisplatin with 500 mL of saline were introduced through the port.
NIPS is done 2 cycles before surgery.
Three weeks after NIPS, 82 patients were eligible to intend cytoreductive surgery (CRS) by gastrectomy + D2 dissection + periotnectomy to achieve complete cytoreduction.
Sixty-eight patients showed positice cytology before NIPS, and the positive cytology results became negative in 47 (69%) patients after NIPS.
Complete pathologic response on PC after NIPS was experienced in 30 (36.8%) patients.
Stage migration was experienced in 12 patients (14.6%).
Complete cytoreduction was achieved in 58 patients (70.7%).
By the multivariate analysis, complete cytoreduction and pathologic response became a significantly good survival.
However the high morbidity and mortality, stringent patient selection is important.
The best indications of the therapy are patients with good pathologic response and PCI≤6, which are supposed to be removed completely by peritonectomy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yonemura, Yutaka& Elnemr, Ayman& Endou, Yoshio& Ishibashi, Haruaki& Mizumoto, Akiyoshi& Miura, Masahiro…[et al.]. 2012. Effects of Neoadjuvant IntraperitonealSystemic Chemotherapy (Bidirectional Chemotherapy) for the Treatment of Patients with Peritoneal Metastasis from Gastric Cancer. International Journal of Surgical Oncology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-449609
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yonemura, Yutaka…[et al.]. Effects of Neoadjuvant IntraperitonealSystemic Chemotherapy (Bidirectional Chemotherapy) for the Treatment of Patients with Peritoneal Metastasis from Gastric Cancer. International Journal of Surgical Oncology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-449609
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yonemura, Yutaka& Elnemr, Ayman& Endou, Yoshio& Ishibashi, Haruaki& Mizumoto, Akiyoshi& Miura, Masahiro…[et al.]. Effects of Neoadjuvant IntraperitonealSystemic Chemotherapy (Bidirectional Chemotherapy) for the Treatment of Patients with Peritoneal Metastasis from Gastric Cancer. International Journal of Surgical Oncology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-449609
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449609
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر