Myricetin Ameliorates Defective Post-Receptor Insulin Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats

المؤلفون المشاركون

Tzeng, Thing-Fong
Liou, Shorong-Shii
Liu, I-Min

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-06-04

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

β-Endorphin plays a major role in the amelioration of insulin resistance.

The present study documents that myricetin (3,5,7,3′,4′,5′-hexahydroxyflavone) ameliorates insulin resistance by enhancing β-endorphin production in insulin-resistant rats.

The rats were induced for insulin resistance by feeding them a diet containing 60% fructose for 6 weeks.

The degree of insulin resistance was measured by the homeostasis model assessment of basal insulin resistance (HOMA-IR).

The plasma levels of insulin and β-endorphin were measured by an enzyme-linked immunosorbent assay.

The insulin receptor-related signaling mediators in the soleus muscles of rats were evaluated by immunoprecipitation or immunoblotting.

Myricetin was injected daily (1 mg kg−1 per injection, thrice daily) for 14 days.

Consequently, the high-glucose plasma levels in fructose-fed rats decreased significantly concomitant with an increase in plasma β-endorphin.

The reduction of the elevated HOMA-IR index following treatment with myricetin was subsequently inhibited by the administration of β-funaltrexamine hydrochloride (β-FNA) at doses sufficient to block μ-opioid receptors (MOR).

The myricetin treatment was also observed to affect the phosphorylation of the insulin receptor, insulin receptor substrate-1, Akt and Akt substrate of 160 kDa, with subsequent effects on glucose-transporter subtype 4 translocation, all of which were blocked by β-FNA pretreatment.

These results indicated that enhancement of β-endorphin secretion, which in turn leads to peripheral MOR activation, is involved in the action of myricetin on the amelioration of impaired signaling intermediates downstream of insulin receptors.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Tzeng, Thing-Fong& Liou, Shorong-Shii& Liu, I-Min. 2011. Myricetin Ameliorates Defective Post-Receptor Insulin Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-449820

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Tzeng, Thing-Fong…[et al.]. Myricetin Ameliorates Defective Post-Receptor Insulin Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-449820

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Tzeng, Thing-Fong& Liou, Shorong-Shii& Liu, I-Min. Myricetin Ameliorates Defective Post-Receptor Insulin Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-449820

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-449820