Detection of Soluble Amyloid-β Oligomers and Insoluble High-Molecular-Weight Particles in CSF : Development of Methods with Potential for Diagnosis and Therapy Monitoring of Alzheimer's Disease
المؤلف
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-11-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The diagnosis of probable Alzheimer's disease (AD) can be established premortem based on clinical criteria like neuropsychological tests.
Post mortem, specific neuropathological changes like amyloid plaques define AD.
However, the standard criteria based on medical history and mental status examinations do not take into account the long preclinical features of the disease, and a biomarker for improved diagnosis of AD is urgently needed.
In a large number of studies, amyloid-β (Aβ) monomer concentrations in CSF of AD patients are consistently and significantly reduced when compared to healthy controls.
Therefore, monomeric Aβ in CSF was suggested to be a helpful biomarker for the diagnosis of preclinical AD.
However, not the monomeric form, but Aβ oligomers have been shown to be the toxic species in AD pathology, and their quantification and characterization could facilitate AD diagnosis and therapy monitoring.
Here, we review the current status of assay development to reliably and routinely detect Aβ oligomers and high-molecular-weight particles in CSF.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Funke, Susanne Aileen. 2011. Detection of Soluble Amyloid-β Oligomers and Insoluble High-Molecular-Weight Particles in CSF : Development of Methods with Potential for Diagnosis and Therapy Monitoring of Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-449896
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Funke, Susanne Aileen. Detection of Soluble Amyloid-β Oligomers and Insoluble High-Molecular-Weight Particles in CSF : Development of Methods with Potential for Diagnosis and Therapy Monitoring of Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-449896
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Funke, Susanne Aileen. Detection of Soluble Amyloid-β Oligomers and Insoluble High-Molecular-Weight Particles in CSF : Development of Methods with Potential for Diagnosis and Therapy Monitoring of Alzheimer's Disease. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-449896
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449896
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر