Jacobsen Catalyst as a Cytochrome P450 Biomimetic Model for the Metabolism of Monensin A
المؤلفون المشاركون
Lopes, Norberto Peporine
de Moraes, Luiz Alberto Beraldo
Assis, Marilda das Dores
de Oliveira, Anderson Rodrigo Moraes
Gates, Paul Jonathan
Berretta, Andresa Aparecida
Dorta, Daniel Junqueira
Pospíšil, Stanislav
Rocha, Bruno Alves
Pazin, Murilo
Rodrigues, Andresa Piacezzi Nascimento
Peti, Ana Paula Ferranti
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-28
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Monensin A is a commercially important natural product isolated from Streptomyces cinnamonensins that is primarily employed to treat coccidiosis.
Monensin A selectively complexes and transports sodium cations across lipid membranes and displays a variety of biological properties.
In this study, we evaluated the Jacobsen catalyst as a cytochrome P450 biomimetic model to investigate the oxidation of monensin A.
Mass spectrometry analysis of the products from these model systems revealed the formation of two products: 3-O-demethyl monensin A and 12-hydroxy monensin A, which are the same ones found in in vivo models.
Monensin A and products obtained in biomimetic model were tested in a mitochondrial toxicity model assessment and an antimicrobial bioassay against Staphylococcus aureus, S.
aureus methicillin-resistant, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Escherichia coli.
Our results demonstrated the toxicological effects of monensin A in isolated rat liver mitochondria but not its products, showing that the metabolism of monensin A is a detoxification metabolism.
In addition, the antimicrobial bioassay showed that monensin A and its products possessed activity against Gram-positive microorganisms but not for Gram-negative microorganisms.
The results revealed the potential of application of this biomimetic chemical model in the synthesis of drug metabolites, providing metabolites for biological tests and other purposes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rocha, Bruno Alves& de Oliveira, Anderson Rodrigo Moraes& Pazin, Murilo& Dorta, Daniel Junqueira& Rodrigues, Andresa Piacezzi Nascimento& Berretta, Andresa Aparecida…[et al.]. 2014. Jacobsen Catalyst as a Cytochrome P450 Biomimetic Model for the Metabolism of Monensin A. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-449939
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rocha, Bruno Alves…[et al.]. Jacobsen Catalyst as a Cytochrome P450 Biomimetic Model for the Metabolism of Monensin A. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-449939
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rocha, Bruno Alves& de Oliveira, Anderson Rodrigo Moraes& Pazin, Murilo& Dorta, Daniel Junqueira& Rodrigues, Andresa Piacezzi Nascimento& Berretta, Andresa Aparecida…[et al.]. Jacobsen Catalyst as a Cytochrome P450 Biomimetic Model for the Metabolism of Monensin A. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-449939
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449939
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر