Controllable Assembly of Hydrophobic Superparamagnetic Iron Oxide Nanoparticle with mPEG-PLA Copolymer and Its Effect on MR Transverse Relaxation Rate
المؤلفون المشاركون
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-09-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
العلوم الهندسية و تكنولوجيا المعلومات
الكيمياء
هندسة مدنية
الملخص EN
Assembly of individual superparamagnetic iron oxide nanoparticles (SPION) into cluster is an effective way to prepare MRI contrast agent with high relaxivity.
In this study, we fabricated SPION clusters with different sizes and configurations by assembly of amphiphilic mPEG-PLA copolymer with hydrophobic SPION in aqueous solution.
The evolution of cluster size and configuration with the amount of copolymer and the effect of cluster size on the transverse relaxivity was studied.
T2 relaxation rates of clusters with different sizes at iron concentration of 0.1 mM were compared with the theoretical predictions.
We found that the relative amount of copolymer/SPION was crucial for the formation of SPION cluster.
The transverse relaxivity of the condense SPION clusters (CSC) was size-dependent.
The experimentally measured T2 relaxation rates of the clusters were lower than the theoretical predictions.
In motional average regime (MAR) region, T2 relaxation rates were more consistent with the theoretical values when transmission electron microscope (TEM) evaluated size was used.
Therefore, for fabrication of SPION clusters with assembly of mPEG-PLA and hydrophobic SPION, delicate balance between the amount of copolymer and SPION should be pursued, and for comparison of experimental T2 relaxation rate with theoretical predictions, TEM evaluated size was more suitable.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xie, Xuan& Zhang, Chunfu. 2010. Controllable Assembly of Hydrophobic Superparamagnetic Iron Oxide Nanoparticle with mPEG-PLA Copolymer and Its Effect on MR Transverse Relaxation Rate. Journal of Nanomaterials،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-449968
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xie, Xuan& Zhang, Chunfu. Controllable Assembly of Hydrophobic Superparamagnetic Iron Oxide Nanoparticle with mPEG-PLA Copolymer and Its Effect on MR Transverse Relaxation Rate. Journal of Nanomaterials No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-449968
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xie, Xuan& Zhang, Chunfu. Controllable Assembly of Hydrophobic Superparamagnetic Iron Oxide Nanoparticle with mPEG-PLA Copolymer and Its Effect on MR Transverse Relaxation Rate. Journal of Nanomaterials. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-449968
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449968
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر