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Changes in the Distribution of the α3 Na+K+ ATPase Subunit in Heterozygous Lurcher Purkinje Cells as a Genetic Model of Chronic Depolarization during Development
المؤلفون المشاركون
McFarland, Rebecca
Vogel, Michael W.
Mariani, Jean
Zanjani, Hadi S.
المصدر
International Journal of Cell Biology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
A common assumption of excitotoxic mechanisms in the nervous system is that the ionic imbalance resulting from overstimulation of glutamate receptors and increased Na+ and Ca++ influx overwhelms cellular energy metabolic systems leading to cell death.
The goal of this study was to examine how a chronic Na+ channel leak current in developing Purkinje cells in the heterozygous Lurcher mutant (+/Lc) affects the expression and distribution of the α3 subunit of the Na+/K+ ATPase pump, a key component of the homeostasis system that maintains ionic equilibrium in neurons.
The expression pattern of the catalytic α3 Na+/K+ ATPase subunit was analyzed by immunohistochemistry, histochemistry, and Western Blots in wild type (WT) and +/Lc cerebella at postnatal days P10, P15, and P25 to determine if there are changes in the distribution of active Na+/K+ ATPase subunits in degenerating Purkinje cells.
The results suggest that the expression of the catalytic α3 subunit is altered in chronically depolarized +/Lc Purkinje cells, although the density of active Na+/K+ ATPase pumps is not significantly altered compared with WT in the cerebellar cortex at P15, and then declines from P15 to P25 in the +/Lc cerebellum as the +/Lc Purkinje cells degenerate.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
McFarland, Rebecca& Zanjani, Hadi S.& Mariani, Jean& Vogel, Michael W.. 2014. Changes in the Distribution of the α3 Na+K+ ATPase Subunit in Heterozygous Lurcher Purkinje Cells as a Genetic Model of Chronic Depolarization during Development. International Journal of Cell Biology،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-449976
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
McFarland, Rebecca…[et al.]. Changes in the Distribution of the α3 Na+K+ ATPase Subunit in Heterozygous Lurcher Purkinje Cells as a Genetic Model of Chronic Depolarization during Development. International Journal of Cell Biology No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-449976
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
McFarland, Rebecca& Zanjani, Hadi S.& Mariani, Jean& Vogel, Michael W.. Changes in the Distribution of the α3 Na+K+ ATPase Subunit in Heterozygous Lurcher Purkinje Cells as a Genetic Model of Chronic Depolarization during Development. International Journal of Cell Biology. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-449976
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449976
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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