Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model
المؤلفون المشاركون
Dauphinot, L.
Potier, M. C.
Delatour, Benoît
Loistron, A.
Dodd, R. H.
Hérault, Y.
Braudeau, J.
Duchon, A.
المصدر
Advances in Pharmacological Sciences
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-10-19
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Decrease of GABAergic transmission has been proposed to improve memory functions.
Indeed, inverse agonists selective for α5 GABA-A-benzodiazepine receptors (α5IA) have promnesiant activity.
Interestingly, we have recently shown that α5IA can rescue cognitive deficits in Ts65Dn mice, a Down syndrome mouse model with altered GABAergic transmission.
Here, we studied the impact of chronic treatment with α5IA on gene expression in the hippocampus of Ts65Dn and control euploid mice after being trained in the Morris water maze task.
In euploid mice, chronic treatment with α5IA increased IEGs expression, particularly of c-Fos and Arc genes.
In Ts65Dn mice, deficits of IEGs activation were completely rescued after treatment with α5IA.
In addition, normalization of Sod1 overexpression in Ts65Dn mice after α5IA treatment was observed.
IEG expression regulation after α5IA treatment following behavioral stimulation could be a contributing factor for both the general promnesiant activity of α5IA and its rescuing effect in Ts65Dn mice alongside signaling cascades that are critical for memory consolidation and cognition.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Braudeau, J.& Dauphinot, L.& Duchon, A.& Loistron, A.& Dodd, R. H.& Hérault, Y.…[et al.]. 2011. Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model. Advances in Pharmacological Sciences،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-450038
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Braudeau, J.…[et al.]. Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model. Advances in Pharmacological Sciences No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-450038
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Braudeau, J.& Dauphinot, L.& Duchon, A.& Loistron, A.& Dodd, R. H.& Hérault, Y.…[et al.]. Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model. Advances in Pharmacological Sciences. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-450038
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450038
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر