Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model
Joint Authors
Dauphinot, L.
Potier, M. C.
Delatour, Benoît
Loistron, A.
Dodd, R. H.
Hérault, Y.
Braudeau, J.
Duchon, A.
Source
Advances in Pharmacological Sciences
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Decrease of GABAergic transmission has been proposed to improve memory functions.
Indeed, inverse agonists selective for α5 GABA-A-benzodiazepine receptors (α5IA) have promnesiant activity.
Interestingly, we have recently shown that α5IA can rescue cognitive deficits in Ts65Dn mice, a Down syndrome mouse model with altered GABAergic transmission.
Here, we studied the impact of chronic treatment with α5IA on gene expression in the hippocampus of Ts65Dn and control euploid mice after being trained in the Morris water maze task.
In euploid mice, chronic treatment with α5IA increased IEGs expression, particularly of c-Fos and Arc genes.
In Ts65Dn mice, deficits of IEGs activation were completely rescued after treatment with α5IA.
In addition, normalization of Sod1 overexpression in Ts65Dn mice after α5IA treatment was observed.
IEG expression regulation after α5IA treatment following behavioral stimulation could be a contributing factor for both the general promnesiant activity of α5IA and its rescuing effect in Ts65Dn mice alongside signaling cascades that are critical for memory consolidation and cognition.
American Psychological Association (APA)
Braudeau, J.& Dauphinot, L.& Duchon, A.& Loistron, A.& Dodd, R. H.& Hérault, Y.…[et al.]. 2011. Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model. Advances in Pharmacological Sciences،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-450038
Modern Language Association (MLA)
Braudeau, J.…[et al.]. Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model. Advances in Pharmacological Sciences No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-450038
American Medical Association (AMA)
Braudeau, J.& Dauphinot, L.& Duchon, A.& Loistron, A.& Dodd, R. H.& Hérault, Y.…[et al.]. Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model. Advances in Pharmacological Sciences. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-450038
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450038