Reduced FAF1 Expression and Helicobacter Infection : Correlations with Clinicopathological Features in Gastric Cancer
المؤلفون المشاركون
Ge, Lian-ying
Ye, Xin-qing
Luo, Xiao-ling
Liu, Ai-qun
Luo, Yuan
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
This study aimed to investigate possible associations between FAF1 expression and aspects of gastric cancer, in particular its clinical characteristics and Helicobacter infection.
Materials and Methods.
RT-PCR and immunohistochemistry were used to analyze expression of FAF1 mRNA and protein in 40 gastric cancer patients.
H.
pylori infection was detected by three staining protocols.
Results.
The expression level of FAF1 mRNA was significantly lower in gastric cancer tissue than in normal gastric mucosa from the same patient (P<0.05).
FAF1 mRNA expression was significantly lower in stage IV gastric cancer than in stage I+II or IIIA+IIIB (P=0.004) and also significantly lower in gastric cancer with distant metastasis.
FAF1 mRNA expression was higher in well-differentiated cancer than in poorly-differentiated cancer (0.39±0.06 versus 0.19±0.06, t=9.966, P<0.01).
FAF1 protein was detected in 15 of 40 (37.5%) cancerous tissue samples and in 29 of 40 (72.5%) corresponding normal tissue samples (P<0.01).
FAF1 mRNA expression was lower in H.
pylori-positive cancerous tissue samples than in H.
pylori-negative ones (P<0.05).
Conclusions.
Downregulation of FAF1 expression may be related to the carcinogenesis and progression of gastric cancer, and H.
pylori infection during gastric carcinogenesis may downregulate FAF1 expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Ai-qun& Ge, Lian-ying& Ye, Xin-qing& Luo, Xiao-ling& Luo, Yuan. 2012. Reduced FAF1 Expression and Helicobacter Infection : Correlations with Clinicopathological Features in Gastric Cancer. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-450039
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Ai-qun…[et al.]. Reduced FAF1 Expression and Helicobacter Infection : Correlations with Clinicopathological Features in Gastric Cancer. Gastroenterology Research and Practice No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-450039
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Ai-qun& Ge, Lian-ying& Ye, Xin-qing& Luo, Xiao-ling& Luo, Yuan. Reduced FAF1 Expression and Helicobacter Infection : Correlations with Clinicopathological Features in Gastric Cancer. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-450039
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450039
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر