Effects of S100B on Serotonergic Plasticity and Neuroinflammation in the Hippocampus in Down Syndrome and Alzheimer's Disease : Studies in an S100B Overexpressing Mouse Model
المؤلفون المشاركون
Shapiro, Lee A.
Bialowas-McGoey, Lynn A.
Whitaker-Azmitia, Patricia M.
المصدر
Cardiovascular Psychiatry and Neurology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-08-22
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
S100B promotes development and maturation in the mammalian brain.
However, prolonged or extensive exposure can lead to neurodegeneration.
Two important functions of S100B in this regard, are its role in the development and plasticity of the serotonergic neurotransmitter system, and its role in the cascade of glial changes associated with neuroinflammation.
Both of these processes are therefore accelerated towards degeneration in disease processes wherein S100B is increased, notably, Alzheimer's disease (AD) and Down syndrome (DS).
In order to study the role of S100B in this context, we have examined S100B overexpressing transgenic mice.
Similar to AD and DS, the transgenic animals show a profound change in serotonin innervation.
By 28 weeks of age, there is a significant loss of terminals in the hippocampus.
Similarly, the transgenic animals show neuroinflammatory changes analogous with AD and DS.
These include decreased numbers of mature, stable astroglial cells, increased numbers of activated microglial cells and increased microglial expression of the cell surface receptor RAGE.
Eventually, the S100B transgenic animals show neurodegeneration and the appearance of hyperphosphorylated tau structures, as seen in late stage DS and AD.
The role of S100B in these conditions is discussed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shapiro, Lee A.& Bialowas-McGoey, Lynn A.& Whitaker-Azmitia, Patricia M.. 2010. Effects of S100B on Serotonergic Plasticity and Neuroinflammation in the Hippocampus in Down Syndrome and Alzheimer's Disease : Studies in an S100B Overexpressing Mouse Model. Cardiovascular Psychiatry and Neurology،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-450073
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shapiro, Lee A.…[et al.]. Effects of S100B on Serotonergic Plasticity and Neuroinflammation in the Hippocampus in Down Syndrome and Alzheimer's Disease : Studies in an S100B Overexpressing Mouse Model. Cardiovascular Psychiatry and Neurology No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-450073
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shapiro, Lee A.& Bialowas-McGoey, Lynn A.& Whitaker-Azmitia, Patricia M.. Effects of S100B on Serotonergic Plasticity and Neuroinflammation in the Hippocampus in Down Syndrome and Alzheimer's Disease : Studies in an S100B Overexpressing Mouse Model. Cardiovascular Psychiatry and Neurology. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-450073
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450073
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر