Association between Cystatin C and MRI Measures of Left Ventricular Structure and Function : Multi-Ethnic Study of Atherosclerosis
المؤلفون المشاركون
Agarwal, Subhashish
Lima, João
Shlipak, Michael G.
Thohan, Vinay
Siscovick, David S.
Herrington, David M.
Bluemke, David A.
Gomes, Antoinette
المصدر
International Journal of Nephrology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-10-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction.
Reduced kidney function, approximated by elevated cystatin C, is associated with diastolic dysfunction, heart failure, and cardiovascular mortality; however, the precise mechanism(s) that account for these relationships remains unclear.
Understanding the relationship between cystatin C and subclinical left ventricular (LV) remodeling, across ethnically diverse populations, may help explain the mechanisms underlying the association of kidney dysfunction with heart failure and cardiovascular mortality.
Methods.
Measures of cystatin C and LV parameters were obtained from the multi-ethnic study of atherosclerosis (MESA) cohort at baseline (N=4,970 with complete data on cystatin C and LV parameters).
LV parameters; LV end-diastolic (LVEDV) and end-systolic volumes (LVESV), LV mass (LVM), concentricity (LV mass/LV end-diastolic volume), and LV ejection fraction (LVEF) were measured using magnetic resonance imaging.
Nested linear models were used to examine the relationship between higher quartiles of cystatin C and LV parameters, with and without adjustment for demographics, height, and weight, and traditional cardiovascular risk factors.
Similar analyses were performed stratified by ethnicity and gender.
Results.
A fully adjusted model demonstrated a linear relationship between higher quartiles of cystatin C and lower LVEDV, (Mean ± SE, 128 ± 0.7, 128 ± 0.7, 126 ± 0.7, 124 ± 0.8 mL; P=0.0001).
Associations were also observed between higher quartiles of cystatin C and lower LVESV (P=0.04) and concentricity (P=0.0001).
In contrast, no association was detected between cystatin C and LVM or LVEF.
In analyses stratified by race and gender, the patterns of association between cystatin C quartiles and LV parameters were qualitatively similar to the overall association.
Conclusion.
Cystatin C levels were inversely associated with LVEDV and LVESV with a disproportionate decrease in LVEDV compared to LVM in a multi-ethnic population.
This morphometric pattern of concentric left ventricular remodeling, may in part explain the process by which kidney dysfunction leads to diastolic dysfunction, heart failure and cardiovascular mortality.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Agarwal, Subhashish& Thohan, Vinay& Shlipak, Michael G.& Lima, João& Bluemke, David A.& Siscovick, David S.…[et al.]. 2011. Association between Cystatin C and MRI Measures of Left Ventricular Structure and Function : Multi-Ethnic Study of Atherosclerosis. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-450097
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Agarwal, Subhashish…[et al.]. Association between Cystatin C and MRI Measures of Left Ventricular Structure and Function : Multi-Ethnic Study of Atherosclerosis. International Journal of Nephrology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-450097
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Agarwal, Subhashish& Thohan, Vinay& Shlipak, Michael G.& Lima, João& Bluemke, David A.& Siscovick, David S.…[et al.]. Association between Cystatin C and MRI Measures of Left Ventricular Structure and Function : Multi-Ethnic Study of Atherosclerosis. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-450097
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450097
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر