Procoagulant and Anticoagulant Factors in Childhood Hypothyroidism

المؤلفون المشاركون

Tapci, Ayse Esra
Dallar, Yildiz
Simsek, Enver
Kilic, Nevin
Alioglu, Bulent
Karamercan, Sirma

المصدر

International Journal of Endocrinology

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-4، 4ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-07-03

دولة النشر

مصر

عدد الصفحات

4

التخصصات الرئيسية

الأحياء

الملخص EN

The aim of this study was to investigate the effects of thyroid hormone deficiencies in childhood on the elements of coagulation proteins.

Consecutive 54 children with hypothyroidism and 55 healthy controls aged 1 month–16 years were enrolled.

One year after Na-L-thyroxine treatment, the study parameters were reevaluated.

Thyroid function tests, procoagulant and anticoagulant proteins were performed for children with hypothyroidism and healthy controls.

Significant decreased results were found in children with hypothyroidism in terms of fibrinogen, TT, and anticoagulant proteins including AT, PC, PS, and fPS.

Significant increases were found with respect to APTT, fibrinogen, and TT.

In the evaluation of posttreatment changes a statistically significant increase was found in vWF, FVIII, AT, PC, PS, and fPS.

A positive correlation was found between fT4 and vWF, FVIII, PC, and PS.

We would like to emphasize that the coagulation system especially vWF and FVIII, and particularly the anticoagulant system, should be monitored closely in patients followed up for hypothyroidism.

Thyroid hormones should be examined and, if necessary, hormone replacement therapy should be administered in patients followed up for a predisposition to coagulation.

Additionally, further studies with larger series are needed to investigate the effects of hypothyroidism on the coagulation system.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kilic, Nevin& Dallar, Yildiz& Simsek, Enver& Karamercan, Sirma& Tapci, Ayse Esra& Alioglu, Bulent. 2012. Procoagulant and Anticoagulant Factors in Childhood Hypothyroidism. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-450314

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kilic, Nevin…[et al.]. Procoagulant and Anticoagulant Factors in Childhood Hypothyroidism. International Journal of Endocrinology No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-450314

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kilic, Nevin& Dallar, Yildiz& Simsek, Enver& Karamercan, Sirma& Tapci, Ayse Esra& Alioglu, Bulent. Procoagulant and Anticoagulant Factors in Childhood Hypothyroidism. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-450314

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-450314