Transplacental Transfer of Hepatitis B Neutralizing Antibody during Pregnancy in an Animal Model : Implications for Newborn and Maternal Health
المؤلفون المشاركون
Mahmood, Iftekhar
Ma, Li
Zhong, Lilin
Struble, Evi Budo
Zhang, Pei
Zhao, Zhong
Norton, Malgorzata G.
المصدر
Hepatitis Research and Treatment
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-27
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Despite the success of postexposure prophylaxis (PEP) of the newborn in preventing mother-to-child transmission of hepatitis B virus), in non-US clinical trials, administering hepatitis B immune globulin (HBIG) to mothers at the end of pregnancy (in addition to passive-active PEP of the newborn) only partially improved outcomes.
That is, a significant percentage of newborns became infected during their first year of life.
We used a relevant animal model for human IgG transplacental transfer to study dose, time and subclass dependence of HBV neutralizing antibody (nAb) maternal, and fetal levels at the end of pregnancy.
Pregnant guinea pigs received 50 or 100 IU/kg HBIGIV 2–5 days before delivery.
Human total IgG, IgG subclasses, and nAb in mothers and their litters were measured.
In vitro analyses of guinea pig Fc neonatal receptor binding to HBIGIV, as well as to all human IgG subclasses, were also performed.
Our study showed that nAb transferred transplacentally from the pregnant guinea pigs to their litters; no transfer occurred during parturition.
The amount of the transferred nAb was dose and time dependent.
Thus, selection of an efficacious dose in the clinic is important: microdosing may be underdosing, particularly in cases of high viraemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Li& Norton, Malgorzata G.& Mahmood, Iftekhar& Zhao, Zhong& Zhong, Lilin& Zhang, Pei…[et al.]. 2014. Transplacental Transfer of Hepatitis B Neutralizing Antibody during Pregnancy in an Animal Model : Implications for Newborn and Maternal Health. Hepatitis Research and Treatment،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-450544
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Li…[et al.]. Transplacental Transfer of Hepatitis B Neutralizing Antibody during Pregnancy in an Animal Model : Implications for Newborn and Maternal Health. Hepatitis Research and Treatment No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-450544
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Li& Norton, Malgorzata G.& Mahmood, Iftekhar& Zhao, Zhong& Zhong, Lilin& Zhang, Pei…[et al.]. Transplacental Transfer of Hepatitis B Neutralizing Antibody during Pregnancy in an Animal Model : Implications for Newborn and Maternal Health. Hepatitis Research and Treatment. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-450544
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450544
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر