Evaluation of the Possible Mechanisms of Antihypertensive Activity of Loranthus micranthus : An African Mistletoe
المؤلفون المشاركون
Hodonu, Sedoten A.
Nwoke, Stella
Agomo, Phillip U.
Iwalokun, Bamidele A.
Ojo, Olabisi
المصدر
Biochemistry Research International
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-09-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Loranthus micranthus (LM), also called African mistletoe is a major Nigerian Loranthaceae plant used traditionally to treat hypertension.
The methanolic leaf extract of the plant (LMME) has been shown to elicit anti-hypertensive activity in rats but mechanism remains unclear.
This study was undertaken to study the effect of LM on pressor-induced contraction of rat aorta smooth muscles and serum lipid profiles in mice.
The LMME was partitioned to produce n-butanol (NBF-LMME), chloroform (CF-LMME), ethyl acetate (EAF-LMME) and water (WF-LMME) fractions.
The median effective concentrations and maximum relaxation of the fractions were determined against epinephrine and KCl pre-contracted rat aorta ring model.
Serum lipid profiles and nitric oxide (NO) were determined spectrophotometrically in mice administered per orally 250 mg/kg b.w.
of each fraction for 21 days.
Data were analyzed statistically.
NBF-LMME elicited the highest dose-dependent inhibitory effect on rat aorta pre-contracted with norepinephrine and KCl, followed in decreasing order by WF-LMME > CF-LMME > EAF-LMME.
Similar order of activity was observed in the ability of these fractions to inhibit elevation in artherogenic lipids, raise serum nitric oxide and reduce cardiac arginase in mice.
We conclude the anti-hypertensive activity of L.
micranthus involve anti-artherogenic events, vasorelaxation, cardiac arginase reduction and NO elevation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Iwalokun, Bamidele A.& Hodonu, Sedoten A.& Nwoke, Stella& Ojo, Olabisi& Agomo, Phillip U.. 2011. Evaluation of the Possible Mechanisms of Antihypertensive Activity of Loranthus micranthus : An African Mistletoe. Biochemistry Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-450572
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Iwalokun, Bamidele A.…[et al.]. Evaluation of the Possible Mechanisms of Antihypertensive Activity of Loranthus micranthus : An African Mistletoe. Biochemistry Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-450572
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Iwalokun, Bamidele A.& Hodonu, Sedoten A.& Nwoke, Stella& Ojo, Olabisi& Agomo, Phillip U.. Evaluation of the Possible Mechanisms of Antihypertensive Activity of Loranthus micranthus : An African Mistletoe. Biochemistry Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-450572
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450572
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر