Mineralization Potential of Electrospun PDO-Hydroxyapatite-Fibrinogen Blended Scaffolds
المؤلفون المشاركون
Yang, Hu
Sell, Scott A.
Rodriguez, Isaac A.
Madurantakam, Parthasarathy A.
Bowlin, Gary L.
McCool, Jennifer M.
Moon, Peter C.
المصدر
International Journal of Biomaterials
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-16
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The current bone autograft procedure for cleft palate repair presents several disadvantages such as limited availability, additional invasive surgery, and donor site morbidity.
The present preliminary study evaluates the mineralization potential of electrospun polydioxanone:nano-hydroxyapatite : fibrinogen (PDO : nHA : Fg) blended scaffolds in different simulated body fluids (SBF).
Scaffolds were fabricated by blending PDO : nHA : Fg in the following percent by weight ratios: 100 : 0 : 0, 50 : 25 : 25, 50 : 50 : 0, 50 : 0 : 50, 0 : 0 : 100, and 0 : 50 : 50.
Samples were immersed in (conventional (c), revised (r), ionic (i), and modified (m)) SBF for 5 and 14 days to induce mineralization.
Scaffolds were characterized before and after mineralization via scanning electron microscopy, Alizarin Red-based assay, and modified burnout test.
The addition of Fg resulted in scaffolds with smaller fiber diameters.
Fg containing scaffolds also induced sheet-like mineralization while individual fiber mineralization was noticed in its absence.
Mineralized electrospun Fg scaffolds without PDO were not mechanically stable after 5 days in SBF, but had superior mineralization capabilities which produced a thick bone-like mineral (BLM) layer throughout the scaffolds.
50 : 50 : 0 scaffolds incubated in either r-SBF for 5 days or c-SBF for 14 days produced scaffolds with high mineral content and individual-mineralized fibers.
These mineralized scaffolds were still porous and will be further optimized as an effective bone substitute in future studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rodriguez, Isaac A.& Madurantakam, Parthasarathy A.& McCool, Jennifer M.& Sell, Scott A.& Yang, Hu& Moon, Peter C.…[et al.]. 2012. Mineralization Potential of Electrospun PDO-Hydroxyapatite-Fibrinogen Blended Scaffolds. International Journal of Biomaterials،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-450578
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rodriguez, Isaac A.…[et al.]. Mineralization Potential of Electrospun PDO-Hydroxyapatite-Fibrinogen Blended Scaffolds. International Journal of Biomaterials No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-450578
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rodriguez, Isaac A.& Madurantakam, Parthasarathy A.& McCool, Jennifer M.& Sell, Scott A.& Yang, Hu& Moon, Peter C.…[et al.]. Mineralization Potential of Electrospun PDO-Hydroxyapatite-Fibrinogen Blended Scaffolds. International Journal of Biomaterials. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-450578
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450578
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر