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Bradykinin Type-2 Receptor Expression Correlates with Age and Is Subjected to Transcriptional Regulation
المؤلفون المشاركون
Kovanen, Petri T.
Liesmaa, Inka
Shiota, Naotaka
Lindstedt, Ken A.
Kokkonen, Jorma O.
المصدر
International Journal of Vascular Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-10-03
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Accumulating work in experimental animals suggests that bradykinin (BK) exerts cardioprotective effects via bradykinin type-2 receptors (BK-2Rs).
In human end-stage heart failure, BK-2Rs are significantly downregulated by mechanisms that have remained elusive.
Heart tissues from idiopathic dilated cardiomyopathy (IDC; n=7), coronary heart disease (CHD; n=6), and normal patients (n=6) were analyzed by RT-PCR, SSCP, and Western blotting.
In normal and IDC hearts, BK-2R expression increased with age, with a lower relative increase in IDC hearts.
BK-2R mRNA and protein levels showed a positive linear correlation, suggesting transcriptional regulation.
Two known BK-2R promoter polymorphisms, −58T/C and −9/+9, were found to be present in the study population.
The allelic frequencies for the C-allele in −58T/C were 0.58 in normal and CHD hearts and 0.81 in IDC hearts.
Furthermore, the allelic frequencies for the −9 and +9 alleles were 0.42 and 0.58 in normal hearts and 0.64 and 0.36 in IDC hearts, respectively.
All analyzed CHD hearts were homozygous for the −9 allele.
Thus, the expression of cardioprotective BK-2Rs in human hearts is increased with age in normal and IDC hearts and may be regulated on the transcriptional level.
Moreover, comparison of normal subjects and patients with failing hearts revealed different allelic frequencies in each of two known BK-2R gene polymorphisms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liesmaa, Inka& Shiota, Naotaka& Kokkonen, Jorma O.& Kovanen, Petri T.& Lindstedt, Ken A.. 2011. Bradykinin Type-2 Receptor Expression Correlates with Age and Is Subjected to Transcriptional Regulation. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-450595
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liesmaa, Inka…[et al.]. Bradykinin Type-2 Receptor Expression Correlates with Age and Is Subjected to Transcriptional Regulation. International Journal of Vascular Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-450595
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liesmaa, Inka& Shiota, Naotaka& Kokkonen, Jorma O.& Kovanen, Petri T.& Lindstedt, Ken A.. Bradykinin Type-2 Receptor Expression Correlates with Age and Is Subjected to Transcriptional Regulation. International Journal of Vascular Medicine. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-450595
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450595
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