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Alterations in Sensitivity to Estrogen, Dihydrotestosterone, and Xenogens in B-Lymphocytes from Children with Autism Spectrum Disorder and Their Unaffected TwinsSiblings
المؤلفون المشاركون
Sharpe, Martyn A.
Gist, Taylor L.
Baskin, David S.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-06
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الطب البشري
الملخص EN
It has been postulated that androgen overexposure in a susceptible person leads to excessive brain masculinization and the autism spectrum disorder (ASD) phenotype.
In this study, the responses to estradiol (E2), dihydrotestosterone (DHT), and dichlorodiphenyldichloroethylene (DDE) on B-lymphocytes from ASD subjects and controls are compared.
B cells were obtained from 11 ASD subjects, their unaffected fraternal twins, and nontwin siblings.
Controls were obtained from a different cell bank.
Lactate dehydrogenase (LDH) and sodium 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) reduction levels were measured after incubation with different concentrations of E2, DHT, and DDE.
XTT/LDH ratio, representative of mitochondria number per cell, was calculated.
E2, DHT, and DDE all cause “U”-shaped growth curves, as measured by LDH levels.
ASD B cells show less growth depression compared to siblings and controls (P<0.01).
They also have reduced XTT/LDH ratios (P<0.01) when compared to external controls, whereas siblings had values of XTT/LDH between ASD and external controls.
B-lymphocytes from people with ASD exhibit a differential response to E2, DHT, and hormone disruptors in regard to cell growth and mitochondrial upregulation when compared to non-ASD siblings and external controls.
Specifically, ASD B-lymphocytes show significantly less growth depression and less mitochondrial upregulation when exposed to these effectors.
A mitochondrial deficit in ASD individuals is implied.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sharpe, Martyn A.& Gist, Taylor L.& Baskin, David S.. 2013. Alterations in Sensitivity to Estrogen, Dihydrotestosterone, and Xenogens in B-Lymphocytes from Children with Autism Spectrum Disorder and Their Unaffected TwinsSiblings. Journal of Toxicology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-450611
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sharpe, Martyn A.…[et al.]. Alterations in Sensitivity to Estrogen, Dihydrotestosterone, and Xenogens in B-Lymphocytes from Children with Autism Spectrum Disorder and Their Unaffected TwinsSiblings. Journal of Toxicology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-450611
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sharpe, Martyn A.& Gist, Taylor L.& Baskin, David S.. Alterations in Sensitivity to Estrogen, Dihydrotestosterone, and Xenogens in B-Lymphocytes from Children with Autism Spectrum Disorder and Their Unaffected TwinsSiblings. Journal of Toxicology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-450611
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450611
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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