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Kaurenoic Acid from Aralia continentalis Inhibits Biofilm Formation of Streptococcus mutans
المؤلفون المشاركون
You, Yong-Ouk
Jeong, Seung-Il
Kim, Beom-Su
Lee, Young-Rae
Kang, Sun-Young
Park, Bok-Im
Lee, Kwang-Hee
Keum, Ki-Suk
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
We isolated a single chemical compound from A.
continentalis and identified it to be kaurenoic acid (KA) and investigated the influence of anticariogenic properties.
Inhibitory effects of KA on cariogenic properties such as growth, acid production, biofilm formation, and the adherence of S.
mutans were evaluated.
Furthermore, real-time PCR analysis was performed to evaluate the influence of KA on the genetic expression of virulence factors.
KA significantly inhibited the growth and acid production of S.
mutans at 2–4 μg/mL and 4 μg/mL of KA, respectively.
Furthermore, the adherence onto S-HAs was inhibited at 3-4 μg/mL of KA and biofilm formation was significantly inhibited when treated with 3 μg/mL KA and completely inhibited at 4 μg/mL.
Also, the inhibitory effect of KA on biofilm formation was confirmed by SEM.
In confocal laser scanning microscopy, bacterial viability gradually decreased by KA in a dose dependent manner.
Real-time PCR analysis showed that the expressions of gtfB, gtfC, gbpB, spaP, brpA, relA, and vicR were significantly decreased in S.
mutans when it was treated with KA.
These results suggest that KA from A.
continentalis may be a useful agent for inhibiting the cariogenic properties of S.
mutans.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jeong, Seung-Il& Kim, Beom-Su& Keum, Ki-Suk& Lee, Kwang-Hee& Kang, Sun-Young& Park, Bok-Im…[et al.]. 2013. Kaurenoic Acid from Aralia continentalis Inhibits Biofilm Formation of Streptococcus mutans. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-450672
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jeong, Seung-Il…[et al.]. Kaurenoic Acid from Aralia continentalis Inhibits Biofilm Formation of Streptococcus mutans. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-450672
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jeong, Seung-Il& Kim, Beom-Su& Keum, Ki-Suk& Lee, Kwang-Hee& Kang, Sun-Young& Park, Bok-Im…[et al.]. Kaurenoic Acid from Aralia continentalis Inhibits Biofilm Formation of Streptococcus mutans. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-450672
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450672
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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