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Serum Omentin-1 as a Disease Activity Marker for Crohn’s Disease
المؤلفون المشاركون
Dong, Xinqian
Lu, Yan
Feng, Yan
Lu, Li
Zhou, Li
Liu, Lifeng
Ren, Xiaoyan
Sang, Weiwei
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-10
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background and Aim.
It remains challenging to determine the inflammatory activity in Crohn’s disease (CD) for lack of specific laboratory markers.
Recent studies suggest that serum omentin-1 is associated with inflammatory response.
We aimed to assess the potential of serum omentin-1 as a marker of disease activity in CD patients.
Methods.
Serum omentin-1 concentrations were determined by enzyme-linked immunosorbent assay (ELISA) in patients with CD (n=240), functional gastrointestinal disorders (FGDs, n=120), and healthy controls (HC, n=60) and evaluated for correlation with disease activity.
Expression of omentin-1 in colonic tissues from patients with CD was also analyzed by real-time PCR and Western blotting.
Serum omentin-1 levels as an activity index were evaluated using a receiver operating characteristic (ROC) curve.
Results.
Serum omentin-1 concentrations were significantly decreased in active CD patients compared with patients in remission, FGDs, and HC (all P<0.001).
Expression of omentin-1 was decreased at mRNA and protein levels in inflamed colonic tissues in active CD than that in noninflamed colonic tissues.
Serum omentin-1 levels were negatively correlated with disease activity in CD, better than C-reactive protein (CRP).
Conclusion.
Our results indicate that serum and colonic omentin-1 expressions are decreased in active CD patients.
The correlation of serum omentin-1 with disease activity in CD is superior to that of CRP.
Serum omentin-1 is a potential marker for CD disease activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Yan& Zhou, Li& Liu, Lifeng& Feng, Yan& Lu, Li& Ren, Xiaoyan…[et al.]. 2014. Serum Omentin-1 as a Disease Activity Marker for Crohn’s Disease. Disease Markers،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-450829
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Yan…[et al.]. Serum Omentin-1 as a Disease Activity Marker for Crohn’s Disease. Disease Markers No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-450829
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Yan& Zhou, Li& Liu, Lifeng& Feng, Yan& Lu, Li& Ren, Xiaoyan…[et al.]. Serum Omentin-1 as a Disease Activity Marker for Crohn’s Disease. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-450829
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450829
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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