Evaluation of the Bronchorelaxant, Genotoxic, and Antigenotoxic Effects of Cassia alata L.
المؤلفون المشاركون
Carreyre, H.
Dibala, C. I.
Vandebrouck, C.
Thibaudeau, S.
Konaté, K.
Belemtougri, R. G.
Fabré, A.
Coustard, J.-M.
Ouédraogo, M.
Da, F. L.
Bescond, J.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-23
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Aqueous-ethanolic extract of Cassia alata (AECal) and its derived fractions obtained through liquid-liquid fractionation were evaluated for their bronchorelaxant, genotoxic, and antigenotoxic effects.
Contractile activity of rats’ tracheas in the presence of tested materials, as well as its modifications with different inhibitors and blockers, was isometrically recorded.
The antigenotoxic potential of AECal was evaluated on cyclophosphamide- (CP-) induced genotoxicity in the rat.
Animals were pretreated with the extract, then liver comet assay was performed.
AECal and its chloroformic fractions (CF-AECal) relaxed the contraction induced by Ach, but both were significantly less potent in inhibiting contraction induced by KCl (30 mM; 80 mM).
Propranolol, indomethacin, L-NAME, methylene blue, and glibenclamide did not modify the relaxant effect of CF-AECal.
TEA altered the response of trachea to CF-AECal.
CF-AECal caused a rightward shift without affecting the Emax in cumulative concentration-response curves of Ach only at low concentrations.
In animals pretreated with the extract, the percentage of CP-induced DNA damage decreased.
Our results suggest that (1) muscarinic receptors contribute at least in part to the relaxant effects of CF-AECal; (2) CF-AECal interferes with membrane polarization; and (3) AECal is not genotoxic in vivo and contains chemopreventive phytoconstituents offering protection against CP-induced genotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ouédraogo, M.& Da, F. L.& Fabré, A.& Konaté, K.& Dibala, C. I.& Carreyre, H.…[et al.]. 2013. Evaluation of the Bronchorelaxant, Genotoxic, and Antigenotoxic Effects of Cassia alata L.. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-450845
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ouédraogo, M.…[et al.]. Evaluation of the Bronchorelaxant, Genotoxic, and Antigenotoxic Effects of Cassia alata L.. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-450845
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ouédraogo, M.& Da, F. L.& Fabré, A.& Konaté, K.& Dibala, C. I.& Carreyre, H.…[et al.]. Evaluation of the Bronchorelaxant, Genotoxic, and Antigenotoxic Effects of Cassia alata L.. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-450845
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450845
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر