Differential Effects of Leptin on the Invasive Potential of Androgen-Dependent and -Independent Prostate Carcinoma Cells
المؤلفون المشاركون
Rao, Shilpa A.
Trock, Bruce J.
Ouhtit, Allal
Bose, Saideep S.
Deo, Dayanand D.
Raj, Madhwa HG
Rao, Prakash N.
Baliga, Surendra B.
Rao, Ashwin P.
Thouta, Rajesh
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2008-06-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Obesity has been linked with an increased risk of prostate cancer.
The formation of toxic free oxygen radicals has been implicated in obesity mediated disease processes.
Leptin is one of the major cytokines produced by adipocytes and controls body weight homeostasis through food intake and energy expenditure.
The rationale of the study was to determine the impact of leptin on the metastatic potential of androgen-sensitive (LNCaP) cells as well as androgen-insensitive (PC-3 and DU-145) cells.
At a concentration of 200_nm, LNCaP cells showed a significant increase (20% above control; P<.0001) in cellular proliferation without any effect on androgen-insensitive cells.
Furthermore, exposure to leptin caused a significant (P<.01 to P<.0001) dose-dependent decrease in migration and invasion of PC3 and Du-145 prostate carcinoma cell lines.
At the molecular level, exposure of androgen-independent prostate cancer cells to leptin stimulates the phosphorylation of MAPK at early time point as well as the transcription factor STAT3, suggesting the activation of the intracellular signaling cascade upon leptin binding to its cognate receptor.
Taken together, these results suggest that leptin mediates the invasive potential of prostate carcinoma cells, and that this effect is dependent on their androgen sensitivity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Deo, Dayanand D.& Rao, Ashwin P.& Bose, Saideep S.& Ouhtit, Allal& Baliga, Surendra B.& Rao, Shilpa A.…[et al.]. 2008. Differential Effects of Leptin on the Invasive Potential of Androgen-Dependent and -Independent Prostate Carcinoma Cells. Journal of Biomedicine and Biotechnology،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-450961
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Deo, Dayanand D.…[et al.]. Differential Effects of Leptin on the Invasive Potential of Androgen-Dependent and -Independent Prostate Carcinoma Cells. Journal of Biomedicine and Biotechnology No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-450961
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Deo, Dayanand D.& Rao, Ashwin P.& Bose, Saideep S.& Ouhtit, Allal& Baliga, Surendra B.& Rao, Shilpa A.…[et al.]. Differential Effects of Leptin on the Invasive Potential of Androgen-Dependent and -Independent Prostate Carcinoma Cells. Journal of Biomedicine and Biotechnology. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-450961
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450961
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر