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Effect of AST-120 on Endothelial Dysfunction in Adenine-Induced Uremic Rats
المؤلفون المشاركون
Seto, Takuya
Watada, Hirotaka
Tomino, Yasuhiko
Kaneko, Kayo
Hotta, Yoko
Inuma, Jiro
Io, Hiroaki
Aruga, Seiki
Hamada, Chieko
Inami, Yuko
Azuma, Kosuke
المصدر
International Journal of Nephrology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
Chronic kidney disease (CKD) represents endothelial dysfunction.
Monocyte adhesion is recognized as the initial step of arteriosclerosis.
Indoxyl sulfate (IS) is considered to be a risk factor for arteriosclerosis in CKD.
Oral adsorbent AST-120 retards deterioration of renal function, reducing accumulation of IS.
In the present study, we determined the monocyte adhesion in the adenine-induced uremic rats in vivo and effects of AST-120 on the adhesion molecules.
Methods.
Twenty-four rats were divided into control, control+AST-120, adenine, and adenine+AST-120 groups.
The number of monocytes adherent to the endothelium of thoracic aorta by imaging the entire endothelial surface and the mRNA expressions of adhesion and atherosclerosis-related molecules were examined on day 49.
The mRNA expressions of ICAM-1 and VCAM-1 in human umbilical vein endothelial cells were also examined.
Results.
Adenine increased the number of adherent monocytes, and AST-120 suppressed the increase.
The monocyte adhesion was related to serum creatinine and IS in sera.
Overexpression of VCAM-1 and TGF-β1 mRNA in the arterial walls was observed in uremic rats.
IS induced increase of the ICAM-1 and VCAM-1 mRNA expressions in vitro.
Conclusion.
It appears that uremic condition introduces the monocyte adhesion to arterial wall and AST-120 might inhibit increasing of the monocyte adherence with CKD progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Inami, Yuko& Hamada, Chieko& Seto, Takuya& Hotta, Yoko& Aruga, Seiki& Inuma, Jiro…[et al.]. 2014. Effect of AST-120 on Endothelial Dysfunction in Adenine-Induced Uremic Rats. International Journal of Nephrology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-450983
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Inami, Yuko…[et al.]. Effect of AST-120 on Endothelial Dysfunction in Adenine-Induced Uremic Rats. International Journal of Nephrology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-450983
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Inami, Yuko& Hamada, Chieko& Seto, Takuya& Hotta, Yoko& Aruga, Seiki& Inuma, Jiro…[et al.]. Effect of AST-120 on Endothelial Dysfunction in Adenine-Induced Uremic Rats. International Journal of Nephrology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-450983
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450983
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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