![](/images/graphics-bg.png)
Superficial Collagen Fibril Modulus and Pericellular Fixed Charge Density Modulate Chondrocyte Volumetric Behaviour in Early Osteoarthritis
المؤلفون المشاركون
Han, Sang Kuy
Turunen, Siru M.
Tanska, Petri
Korhonen, Rami K.
Julkunen, Petro
Herzog, Walter
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-24
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The aim of this study was to investigate if the experimentally detected altered chondrocyte volumetric behavior in early osteoarthritis can be explained by changes in the extracellular and pericellular matrix properties of cartilage.
Based on our own experimental tests and the literature, the structural and mechanical parameters for normal and osteoarthritic cartilage were implemented into a multiscale fibril-reinforced poroelastic swelling model.
Model simulations were compared with experimentally observed cell volume changes in mechanically loaded cartilage, obtained from anterior cruciate ligament transected rabbit knees.
We found that the cell volume increased by 7% in the osteoarthritic cartilage model following mechanical loading of the tissue.
In contrast, the cell volume decreased by 4% in normal cartilage model.
These findings were consistent with the experimental results.
Increased local transversal tissue strain due to the reduced collagen fibril stiffness accompanied with the reduced fixed charge density of the pericellular matrix could increase the cell volume up to 12%.
These findings suggest that the increase in the cell volume in mechanically loaded osteoarthritic cartilage is primarily explained by the reduction in the pericellular fixed charge density, while the superficial collagen fibril stiffness is suggested to contribute secondarily to the cell volume behavior.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tanska, Petri& Turunen, Siru M.& Han, Sang Kuy& Julkunen, Petro& Herzog, Walter& Korhonen, Rami K.. 2013. Superficial Collagen Fibril Modulus and Pericellular Fixed Charge Density Modulate Chondrocyte Volumetric Behaviour in Early Osteoarthritis. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-450988
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tanska, Petri…[et al.]. Superficial Collagen Fibril Modulus and Pericellular Fixed Charge Density Modulate Chondrocyte Volumetric Behaviour in Early Osteoarthritis. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-450988
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tanska, Petri& Turunen, Siru M.& Han, Sang Kuy& Julkunen, Petro& Herzog, Walter& Korhonen, Rami K.. Superficial Collagen Fibril Modulus and Pericellular Fixed Charge Density Modulate Chondrocyte Volumetric Behaviour in Early Osteoarthritis. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-450988
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450988
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)