HIV-1 Trans Infection of CD4+ T Cells by Professional Antigen Presenting Cells

المؤلف

Rinaldo, Charles R.

المصدر

Scientifica

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-30، 30ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-05-07

دولة النشر

مصر

عدد الصفحات

30

التخصصات الرئيسية

العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأمراض

الملخص EN

Since the 1990s we have known of the fascinating ability of a complex set of professional antigen presenting cells (APCs; dendritic cells, monocytes/macrophages, and B lymphocytes) to mediate HIV-1 trans infection of CD4+ T cells.

This results in a burst of virus replication in the T cells that is much greater than that resulting from direct, cis infection of either APC or T cells, or trans infection between T cells.

Such APC-to-T cell trans infection first involves a complex set of virus subtype, attachment, entry, and replication patterns that have many similarities among APC, as well as distinct differences related to virus receptors, intracellular trafficking, and productive and nonproductive replication pathways.

The end result is that HIV-1 can sequester within the APC for several days and be transmitted via membrane extensions intracellularly and extracellularly to T cells across the virologic synapse.

Virus replication requires activated T cells that can develop concurrently with the events of virus transmission.

Further research is essential to fill the many gaps in our understanding of these trans infection processes and their role in natural HIV-1 infection.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Rinaldo, Charles R.. 2013. HIV-1 Trans Infection of CD4+ T Cells by Professional Antigen Presenting Cells. Scientifica،Vol. 2013, no. 2013, pp.1-30.
https://search.emarefa.net/detail/BIM-450993

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Rinaldo, Charles R.. HIV-1 Trans Infection of CD4+ T Cells by Professional Antigen Presenting Cells. Scientifica No. 2013 (2013), pp.1-30.
https://search.emarefa.net/detail/BIM-450993

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Rinaldo, Charles R.. HIV-1 Trans Infection of CD4+ T Cells by Professional Antigen Presenting Cells. Scientifica. 2013. Vol. 2013, no. 2013, pp.1-30.
https://search.emarefa.net/detail/BIM-450993

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-450993