Locally Different Endothelial Nitric Oxide Synthase Protein Levels in Ascending Aortic Aneurysms of Bicuspid and Tricuspid Aortic Valve
المؤلفون المشاركون
Karluss, Antje
Belge, Gazanfer
Nimzyk, Rolf
Radtke, Arlo
Sievers, Hans H.
Saraei, Roza
Bullerdiek, Joern
Sorani, Hajar
Mohamed, Salah A.
المصدر
Cardiology Research and Practice
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aims.
Dysregulated expression of the endothelial nitric oxide synthase (eNOS) is observed in aortic aneurysms associated with bicuspid aortic valve (BAV).
We determined eNOS protein levels in various areas in ascending aortic aneurysms.
Methods and Results.
Aneurysmal specimens were collected from 19 patients, 14 with BAV and 5 with tricuspid aortic valve (TAV).
ENOS protein levels were measured in the outer curve (convexity), the opposite side (concavity), the distal and above the sinotubular junction (proximal) aneurysm.
Cultured aortic cells were treated with NO synthesis inhibitor L-NAME and the amounts of 35 apoptosis-related proteins were determined.
In patients with BAV, eNOS levels were significantly lower in the proximal aorta than in the concavity and distal aorta.
ENOS protein levels were also lower in the convexity than in the concavity.
While the convexity and distal aorta showed similar eNOS protein levels in BAV and TAV patients, levels were higher in TAV proximal aorta.
Inhibition of NO synthesis in aneurysmal aortic cells by L-NAME led to a cytosolic increase in the levels of mitochondrial serine protease HTRA2/Omi.
Conclusion.
ENOS protein levels were varied at different areas of the aneurysmal aorta.
The dysregulation of nitric oxide can lead to an increase in proapoptotic HTRA2/Omi.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mohamed, Salah A.& Radtke, Arlo& Saraei, Roza& Bullerdiek, Joern& Sorani, Hajar& Nimzyk, Rolf…[et al.]. 2012. Locally Different Endothelial Nitric Oxide Synthase Protein Levels in Ascending Aortic Aneurysms of Bicuspid and Tricuspid Aortic Valve. Cardiology Research and Practice،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-451168
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mohamed, Salah A.…[et al.]. Locally Different Endothelial Nitric Oxide Synthase Protein Levels in Ascending Aortic Aneurysms of Bicuspid and Tricuspid Aortic Valve. Cardiology Research and Practice No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-451168
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mohamed, Salah A.& Radtke, Arlo& Saraei, Roza& Bullerdiek, Joern& Sorani, Hajar& Nimzyk, Rolf…[et al.]. Locally Different Endothelial Nitric Oxide Synthase Protein Levels in Ascending Aortic Aneurysms of Bicuspid and Tricuspid Aortic Valve. Cardiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-451168
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-451168
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر