![](/images/graphics-bg.png)
Human Lipoxygenase Pathway Gene Variation and Association with Markers of Subclinical Atherosclerosis in the Diabetes Heart Study
المؤلفون المشاركون
Liu, Yongmei
Rich, Stephen S.
Lehtinen, Allison B.
Langefeld, Carl D.
Rudock, Megan E.
Register, Thomas C.
Carr, J. Jeffrey
Bowden, Donald W.
Burdon, Kathryn P.
Freedman, Barry I.
Hedrick, Catherine C.
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-05-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Aims.
Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis.
We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds.
Methods.
Families with two or more siblings with type 2 diabetes and their nondiabetic siblings were studied as part of the Diabetes Heart Study (DHS).
European American diabetic (n=828) and nondiabetic (n=170) siblings were genotyped for SNPs in the ALOX12, ALOX15, ALOX5, and ALOX5AP genes.
Subclinical measures of atherosclerosis (IMT, coronary (CorCP), carotid (CarCP) and aortic (AorCP) calcified plaque) were obtained.
Results.
Associations were observed between ALOX12 with CorCP, ALOX5 with CorCP, AorCP, and IMT, and ALOX5AP with CorCP and CarCP, independent of known epidemiologic risk factors.
Further, lipoxygenase pathway SNPs that were associated with measures of atherosclerosis were associated with markers of inflammation (CRP, ICAM-1) and calcification (MGP).
Conclusions.
Polymorphisms within ALOX12, ALOX5, and ALOX5AP are genetically associated with subclinical atherosclerosis and with biomarkers of disease in families with type 2 diabetes.
These results suggest that variants in lipoxygenase pathway genes may have pleiotropic effects on multiple components that determine risk of cardiovascular disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Burdon, Kathryn P.& Rudock, Megan E.& Lehtinen, Allison B.& Langefeld, Carl D.& Bowden, Donald W.& Register, Thomas C.…[et al.]. 2010. Human Lipoxygenase Pathway Gene Variation and Association with Markers of Subclinical Atherosclerosis in the Diabetes Heart Study. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-451456
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Burdon, Kathryn P.…[et al.]. Human Lipoxygenase Pathway Gene Variation and Association with Markers of Subclinical Atherosclerosis in the Diabetes Heart Study. Mediators of Inflammation No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-451456
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Burdon, Kathryn P.& Rudock, Megan E.& Lehtinen, Allison B.& Langefeld, Carl D.& Bowden, Donald W.& Register, Thomas C.…[et al.]. Human Lipoxygenase Pathway Gene Variation and Association with Markers of Subclinical Atherosclerosis in the Diabetes Heart Study. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-451456
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-451456
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)