Xenograft Enriched with Autologous Bone Marrow in Inlay Reconstructions : A Tomographic and Histomorphometric Study in Rabbit Calvaria

الملخص EN

Objective.

The aim of this study was to evaluate the bone healing after the usage of a scaffold enriched with bone marrow.

Study Design.

Ten rabbits were divided into 2 groups of 5 animals.

Bilateral 12 mm diameter defects were created in the parietal bones.

In control group Bio-Oss were inserted in both defects and, in experimental group, Bio-Oss enriched with autologous bone marrow were inserted in both defects.

In these two groups, one of the calvarial defects was covered with Bio-Gide.

The rabbits were sacrified 8 weeks after surgery and both CT and histomorphometric analysis were done.

Results.

The CT showed a lower remaining defect area in the experimental group covered with Bio-Gide when compared with control group, with and without Bio-Gide.

The histomorphometrics showed no difference between groups regarding the non-vital mineralized tissue area.

For vital mineralized tissue area, the experimental group covered with Bio-Gide obtained a higher percentage area when compared with control group, with and without Bio-Gide.

For non-mineralized tissue area, the experimental group covered with Bio-Gide obtained a lower percentage area when compared with control group, with and without Bio-Gide.

Conclusion.

Both autologous bone marrow and membrane can contribute to the enhancement of bone healing.