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Vasoconstriction Potency Induced by Aminoamide Local Anesthetics Correlates with Lipid Solubility
المؤلفون المشاركون
Son, Yong Hyeok
Chung, Young-Kyun
Kim, Jun Kyu
Lim, Dong Hoon
Sohn, Jin-Young
Ok, Seong-Ho
Shin, Il-Woo
Sohn, Ju-Tae
Lee, Heon-Keun
Sung, Hui-Jin
Choi, Mun-Jeoung
Han, Jeong Yeol
Lee, Soo Hee
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-17
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aminoamide local anesthetics induce vasoconstriction in vivo and in vitro.
The goals of this in vitro study were to investigate the potency of local anesthetic-induced vasoconstriction and to identify the physicochemical property (octanol/buffer partition coefficient, pKa, molecular weight, or potency) of local anesthetics that determines their potency in inducing isolated rat aortic ring contraction.
Cumulative concentration-response curves to local anesthetics (levobupivacaine, ropivacaine, lidocaine, and mepivacaine) were obtained from isolated rat aorta.
Regression analyses were performed to determine the relationship between the reported physicochemical properties of local anesthetics and the local anesthetic concentration that produced 50% (ED50) of the local anesthetic-induced maximum vasoconstriction.
We determined the order of potency (ED50) of vasoconstriction among local anesthetics to be levobupivacaine > ropivacaine > lidocaine > mepivacaine.
The relative importance of the independent variables that affect the vasoconstriction potency is octanol/buffer partition coefficient > potency > pKa > molecular weight.
The ED50 in endothelium-denuded aorta negatively correlated with the octanol/buffer partition coefficient of local anesthetics (r2=0.9563; P<0.001).
The potency of the vasoconstriction in the endothelium-denuded aorta induced by local anesthetics is determined primarily by lipid solubility and, in part, by other physicochemical properties including potency and pKa.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sung, Hui-Jin& Ok, Seong-Ho& Sohn, Jin-Young& Son, Yong Hyeok& Kim, Jun Kyu& Lee, Soo Hee…[et al.]. 2012. Vasoconstriction Potency Induced by Aminoamide Local Anesthetics Correlates with Lipid Solubility. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-451540
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sung, Hui-Jin…[et al.]. Vasoconstriction Potency Induced by Aminoamide Local Anesthetics Correlates with Lipid Solubility. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-451540
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sung, Hui-Jin& Ok, Seong-Ho& Sohn, Jin-Young& Son, Yong Hyeok& Kim, Jun Kyu& Lee, Soo Hee…[et al.]. Vasoconstriction Potency Induced by Aminoamide Local Anesthetics Correlates with Lipid Solubility. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-451540
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-451540
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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